PARP1 - poly (ADP-ribose) polymerase 1
Entrez Gene Name: poly (ADP-ribose) polymerase 1
Entrez GeneID: Human(142)
, Mouse(11545), Rat(25591)
, Mouse(11545), Rat(25591) Synonyms: 5830444G22Rik, Adprp, Adprp1, ADPRT, ADPRT1, AI893648, C80510, MGC93658, PADPRT, pADPRT-1, PARP, PARP1, PARS, POLY(ADP-RIBOSE) POLYMERASE 1, PPOL, sPARP-1
Gene Summary
- Human (142): This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq]
- Rat (25591): catalyzes poly (ADP-ribose) protein modification; plays a role in DNA repair and genome stability [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
base-excision repair, DNA damage response, detection of DNA damage, DNA metabolic process, DNA repair, protein amino acid ADP-ribosylation, protein autoprocessing, regulation of growth rate, response to DNA damage stimulus, telomere maintenance, transcription from RNA polymerase II promoter
Literature References
- 18299389Olabisi OA, Soto-Nieves N, Nieves E, Yang TT, Yang X, Yu RY, Suk HY, Macian F, Chow CW. Regulation of transcription factor NFAT by ADP-ribosylation.Mol Cell Biol 2008 May 01;28(9):2860-71
- 17881537Paquet-Durand F, Silva J, Talukdar T, Johnson LE, Azadi S, van Veen T, Ueffing M, Hauck SM, Ekström PA. Excessive activation of poly(ADP-ribose) polymerase contributes to inherited photoreceptor degeneration in the retinal degeneration 1 mouse.J Neurosci 2007 Sep 19;27(38):10311-9
- 17438151Oumouna-Benachour K, Hans CP, Suzuki Y, Naura A, Datta R, Belmadani S, Fallon K, Woods C, Boulares AH. Poly(ADP-ribose) polymerase inhibition reduces atherosclerotic plaque size and promotes factors of plaque stability in apolipoprotein E-deficient mice: effects on macrophage recruitment, nuclear factor-kappaB nuclear translocation, and foam cell death.Circulation 2007 May 08;115(18):2442-50 View 2322 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, identical protein binding, metal ion binding, NAD or NADH binding, NAD+ ADP-ribosyltransferase activity, protein binding, protein N-terminus binding, transferase activity, transferase activity, transferring glycosyl groups, transferase activity, transferring pentosyl groups, zinc ion binding
Protein Domains
Brca1 carboxy terminal domain, catalytic domain, DNA binding, DNA binding domain, enzyme, NAD ADP-ribosyltransferase, PARP-type zinc finger domain, protein binding, protein N-terminus binding, protein self binding, regulatory domain
Subcellular Locations
centromeres, detergent resistant lipid raft fraction, insoluble fractions, membrane fraction, nuclear fraction, nucleoli, nucleus, plasma membrane, soluble fraction
