DRD1 - dopamine receptor D1
Entrez Gene Name: dopamine receptor D1
Entrez GeneID: Human(1812)
, Mouse(13488), Rat(24316)
, Mouse(13488), Rat(24316) Synonyms: C030036C15Rik, D1, D1 RECEPTOR, D1 receptors, D1A, D1DR, D1R, DADR, DOPAMINE D1 RECEPTOR, DOPAMINE D1D RECEPTOR, DRD1, Drd1a, Gpcr15
Gene Summary
- Human (1812): This gene encodes the D1 subtype of the dopamine receptor. The D1 subtype is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. D1 receptors regulate neuronal growth and development, mediate some behavioral responses, and modulate dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. [provided by RefSeq]
- Rat (24316): induces dopamine sensitive adenylate cyclase activation; plays a role in regulating food intake [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity, activation of adenylate cyclase activity by dopamine receptor signaling pathway, activation of phospholipase C activity by dopamine receptor signaling pathway, adult walking behavior, associative learning, astrocyte development, behavior, behavioral fear response, behavioral response to cocaine, calcium-mediated signaling, cellular response to insulin stimulus, cerebral cortex GABAergic interneuron migration, conditioned taste aversion, dentate gyrus development, dopamine receptor signaling pathway, dopamine transport, eating behavior, elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating), feeding behavior, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, glucose import, grooming behavior, hippocampus development, intracellular protein transport, learning, locomotory behavior, long term synaptic depression, long-term synaptic potentiation, mating behavior, memory, muscle contraction, negative regulation of cell migration, negative regulation of circadian sleep/wake cycle, sleep, negative regulation of protein kinase activity, operant conditioning, peristalsis, phosphatidylinositol catabolic process, phosphoinositide metabolic process, positive regulation of cAMP biosynthetic process, positive regulation of cell migration, positive regulation of potassium ion transport, positive regulation of release of sequestered calcium ion into cytosol, positive regulation of synaptic transmission, glutamatergic, prepulse inhibition, protein import into nucleus, regulation of action potential in neuron, regulation of dopamine metabolic process, regulation of dopamine uptake, regulation of ion transport, regulation of long-term neuronal synaptic plasticity, response to amphetamine, response to cocaine, response to drug, sensitization, signal transduction, startle response, striatum development, synaptic transmission, dopaminergic, synaptogenesis, temperature homeostasis, transmission of nerve impulse, visual learning
Cellular Components
axon, caveola, cell soma, dendrite, dendritic spine, endoplasmic reticulum, endoplasmic reticulum membrane, integral to membrane, integral to plasma membrane, membrane, membrane fraction, nucleus, plasma membrane
Literature References
- 17646043Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferré S. Adenosine A2A receptors and basal ganglia physiology.Prog Neurobiol 2007 Dec 01;83(5):277-92
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
- 17369255Zhang J, Vinuela A, Neely MH, Hallett PJ, Grant SG, Miller GM, Isacson O, Caron MG, Yao WD. Inhibition of the Dopamine D1 Receptor Signaling by PSD-95.J Biol Chem 2007 May 25;282(21):15778-89 View 1485 categorized literature findings and their references in IPA
Molecular Functions
dopamine D1 receptor activity, dopamine receptor activity, dopamine receptor activity, coupled via Gs, drug binding, G-protein coupled receptor activity, protein binding, receptor activity, signal transducer activity
Protein Domains
carboxy terminal domain, cytoplasmic domain, dopamine D1 receptor, dopamine receptor, drug binding, G-protein coupled receptor, protein binding
Subcellular Locations
axons, brush border, cell body, cell surface, cellular membrane, cytoplasm, cytosol, dendrites, dendritic spines, dendritic trees, intracellular membranes, membrane fraction, neurites, plasma membrane, postsynaptic density (PSD) fractions, presynaptic regions
