CUL3 - cullin 3
Entrez Gene Name: cullin 3
Entrez GeneID: Human(8452)
, Mouse(26554), Rat(301555)
, Mouse(26554), Rat(301555) Synonyms: AI467304, AW146203, CUL3, MGC189292, mKIAA0617
Gene Summary
- Human (8452): CUL3 is a component of a ubiquitin E3 ligase that is essential for mitotic division (Sumara et al., 2007 [PubMed 17543862]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle arrest, cell morphogenesis, cyclin catabolic process, G1/S transition of mitotic cell cycle, gastrulation, in utero embryonic development, induction of apoptosis by intracellular signals, modification-dependent protein catabolic process, positive regulation of cell proliferation, trophectodermal cellular morphogenesis, ubiquitin-dependent protein catabolic process
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 10500095Singer JD, Gurian-West M, Clurman B, Roberts JM. Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.Genes Dev 1999 09 15;13(18):2375-87
- 17699672Shen H, Korutla L, Champtiaux N, Toda S, LaLumiere R, Vallone J, Klugmann M, Blendy JA, Mackler SA, Kalivas PW. NAC1 regulates the recruitment of the proteasome complex into dendritic spines.J Neurosci 2007 Aug 15;27(33):8903-13 View 229 categorized literature findings and their references in IPA
Subcellular Locations
cell body, cytoplasm, dendrites, Golgi apparatus, nuclear scaffolds, nuclear speckles, nucleosomes, nucleus
