GRIN2B - glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Entrez Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Entrez GeneID: Human(2904)
, Mouse(14812), Rat(24410)
, Mouse(14812), Rat(24410) Synonyms: AW490526, GluR epsilon 2, GRIN2B, hNR3, MGC142178, MGC142180, NMDA RECEPTOR 2B, Nmda Receptor epsilon2, NMDAR2B, NR2, NR2B
Gene Summary
- Human (2904): N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq]
- Rat (24410): subunit of the NMDA receptor glutamate gated ion channel; displays voltage dependent sensitivity to magnesium, calcium permeability, and glycine regulated activity; may facilitate learning and long term potentiation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
associative learning, behavioral fear response, behavioral response to pain, calcium ion transport, cation transport, detection of mechanical stimulus involved in sensory perception of pain, embryonic development, fear response, glutamate signaling pathway, in utero embryonic development, ion transport, ionotropic glutamate receptor signaling pathway, learning, learning or memory, memory, positive regulation of glutamate secretion, regulation of action potential, regulation of excitatory postsynaptic membrane potential, regulation of long-term neuronal synaptic plasticity, regulation of MAPKKK cascade, regulation of neuronal synaptic plasticity, regulation of postsynaptic membrane potential, regulation of synaptic plasticity, response to ethanol, rhythmic process, sensory organ development, startle response, suckling behavior, synaptic transmission, transport
Cellular Components
cell junction, dendritic spine, integral to membrane, integral to plasma membrane, membrane, membrane fraction, N-methyl-D-aspartate selective glutamate receptor complex, neuron projection, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic membrane, synapse, synaptic cleft, synaptic vesicle, synaptosome, Z disc
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 17962190Jurd R, Thornton C, Wang J, Luong K, Phamluong K, Kharazia V, Gibb SL, Ron D. Mind Bomb-2 Is an E3 Ligase That Ubiquitinates the N-Methyl-D-aspartate Receptor NR2B Subunit in a Phosphorylation-dependent Manner.J Biol Chem 2008 Jan 04;283(1):301-10
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53 View 2118 categorized literature findings and their references in IPA
Molecular Functions
calcium channel activity, calcium ion binding, cation channel activity, cell adhesion molecule binding, D2 dopamine receptor binding, extracellular-glutamate-gated ion channel activity, glycine binding, ion channel activity, ionotropic glutamate receptor activity, magnesium ion binding, N-methyl-D-aspartate selective glutamate receptor activity, neurotransmitter binding, protein binding, protein heterodimerization activity, receptor activity
Protein Domains
calcium channel, carboxy terminal domain, cation channel, extracellular ligand binding domain, glutamate-gated ion channel, glycine binding, ion channel, ionotropic glutamate receptor, N-methyl-D-aspartate selective glutamate receptor, neurotransmitter binding, protein binding, protein heterodimerization
Subcellular Locations
cell body, cellular membrane, cytoplasm, dendrites, dendritic branches, dendritic spines, membrane fraction, plasma membrane, postsynaptic density, postsynaptic density (PSD) fractions, soluble fraction, synapse, synaptic plasma membrane fractions, synaptic vesicle fractions, synaptosomal fractions, synaptosomes, vesicle fraction, vesicles, Z line
