EPHX2 - epoxide hydrolase 2, cytoplasmic
Entrez Gene Name: epoxide hydrolase 2, cytoplasmic
Entrez GeneID: Human(2053)
, Mouse(13850), Rat(65030)
, Mouse(13850), Rat(65030) Synonyms: AW106936, CEH, Cytosolic Epoxide Hydrolase, Eph2, EPHX2, Epoxide Hydrolase 2, Cytoplasmic, SEH, Soluble epoxide hydrolase
Gene Summary
- Human (2053): This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq]
- Rat (65030): catalyzes the hydrolysis of an epoxide to a glycol; plays a role in regulation of blood pressure [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulates:
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Biological Process
aromatic compound catabolic process, cellular calcium ion homeostasis, drug metabolic process, inflammatory response, linoleic acid metabolic process, metabolic process, oxygen and reactive oxygen species metabolic process, positive regulation of blood pressure, positive regulation of vasodilation, prostaglandin production during acute inflammatory response, response to toxin, sensory perception of pain, xenobiotic metabolic process
Literature References
- 17495027Ai D, Fu Y, Guo D, Tanaka H, Wang N, Tang C, Hammock BD, Shyy JY, Zhu Y. Angiotensin II up-regulates soluble epoxide hydrolase in vascular endothelium in vitro and in vivo.Proc Natl Acad Sci U S A 2007 May 22;104(21):9018-23
- 17460077Koerner IP, Jacks R, DeBarber AE, Koop D, Mao P, Grant DF, Alkayed NJ. Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury.J Neurosci 2007 Apr 25;27(17):4642-9
- 17135253Luria A, Weldon SM, Kabcenell AK, Ingraham RH, Matera D, Jiang H, Gill R, Morisseau C, Newman JW, Hammock BD. Compensatory Mechanism for Homeostatic Blood Pressure Regulation in Ephx2 Gene-disrupted Mice.J Biol Chem 2007 Feb 02;282(5):2891-8 View 106 categorized literature findings and their references in IPA
Molecular Functions
4-nitrophenylphosphatase activity, catalytic activity, epoxide hydrolase activity, hydrolase activity, magnesium ion binding, metal ion binding, protein homodimerization activity
