FOXO4 - forkhead box O4
Entrez Gene Name: forkhead box O4
Entrez GeneID: Human(4303)
, Mouse(54601), Rat(302415)
, Mouse(54601), Rat(302415) Synonyms: AFX, AFX1, Afxh, FOXO4, MGC117660, MGC120490, MLLT7, RGD1561201
Gene Summary
No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cell cycle, cell cycle arrest, cell differentiation, G1 phase of mitotic cell cycle, insulin receptor signaling pathway, mitotic cell cycle G2/M transition DNA damage checkpoint, multicellular organismal development, muscle organ development, negative regulation of angiogenesis, negative regulation of cell proliferation, negative regulation of smooth muscle cell differentiation, positive regulation of transcription, regulation of transcription, DNA-dependent, skeletal muscle tissue development, transcription, transcription from RNA polymerase II promoter
Literature References
- 15538382Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, Burgering BM. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.EMBO J 2004 Dec 08;23(24):4802-12
- 15084259Seoane J, Le HV, Shen L, Anderson SA, Massague J. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation.Cell 2004 04 16;117(2):211-23
- 17242183Li H, Liang J, Castrillon DH, Depinho RA, Olson EN, Liu ZP. FoxO4 Regulates Tumor Necrosis Factor Alpha-Directed Smooth Muscle Cell Migration by Activating Matrix Metalloproteinase 9 Gene Transcription.Mol Cell Biol 2007 Apr 01;27(7):2676-86 View 250 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, enzyme binding, sequence-specific DNA binding, transcription activator activity, transcription factor activity, transcription factor binding
Protein Domains
CR2 domain, DNA binding domain, enzyme binding, transcription factor, transcription factor binding, transcription regulator, transcriptional activator, winged helix domain
