UTS2 - urotensin 2
Entrez Gene Name: urotensin 2
Entrez GeneID: Human(10911)
, Mouse(24111), Rat(29180)
, Mouse(24111), Rat(29180) Synonyms: MGC130253, MGC130254, prepro-UII, PRO1068, U-II, UCN2, Urocortin 2, UTS2
Gene Summary
- Human (10911): This gene encodes a mature peptide that is an active cyclic heptapeptide absolutely conserved from lamprey to human. The active peptide acts as a vasoconstrictor and is expressed only in brain tissue. Despite the gene family name similarity, this gene is not homologous to urocortin, a member of the sauvagine/corticotropin-releasing factor/urotensin I family. Most of the proprotein is cleaved to make the mature peptide. Transcript variants encoding different preproprotein isoforms have been described for this gene. [provided by RefSeq]
- Rat (29180): a cyclic neuropeptide; may be involved in the control of neuromuscular functions [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
elevation of cytosolic calcium ion concentration, muscle contraction, negative regulation of blood pressure, negative regulation of diuresis, negative regulation of glomerular filtration, negative regulation of heart rate, negative regulation of insulin secretion, negative regulation of natriuresis, positive regulation of angiogenesis, positive regulation of blood pressure, positive regulation of cell differentiation, positive regulation of circadian sleep/wake cycle, REM sleep, positive regulation of circadian sleep/wake cycle, wakefulness, positive regulation of collagen biosynthetic process, positive regulation of fibroblast migration, positive regulation of fibroblast proliferation, positive regulation of heart rate, positive regulation of synaptic transmission, cholinergic, positive regulation of vasodilation, regulation of blood pressure, response to drug, response to hypoxia, response to testosterone stimulus, synaptic transmission
Literature References
- 14736736Chen A, Blount A, Vaughan J, Brar B, Vale W. Urocortin II gene is highly expressed in mouse skin and skeletal muscle tissues: localization, basal expression in CRFR1 and CRFR2- mice and regulation by glucocorticoids.Endocrinology 2004 05 1;145(5):2445-57
- 10499587Ames RS, Sarau HM, Chambers JK, Willette RN, Aiyar NV, Romanic AM, Louden CS, Foley JJ, Sauermelch CF, Coatney RW, Ao Z, Disa J, Holmes SD, Stadel JM, Martin JD, Liu WS, Glover GI, Wilson S, McNulty DE, Ellis CE, Elshourbagy NA, Shabon U, Trill JJ, Hay DW, Douglas SA. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.Nature 1999 Sep 16;401(6750):282-6
- 12807997Brkovic A, Hattenberger A, Kostenis E, Klabunde T, Flohr S, Kurz M, Bourgault S, Fournier A. Functional and binding characterizations of urotensin II-related peptides in human and rat urotensin II-receptor assay.J Pharmacol Exp Ther 2003 Sep 01;306(3):1200-9 View 333 categorized literature findings and their references in IPA
