KALRN - kalirin, RhoGEF kinase
Entrez Gene Name: kalirin, RhoGEF kinase
Entrez GeneID: Human(8997)
, Mouse(545156), Rat(84009)
, Mouse(545156), Rat(84009) Synonyms: 2210407G14RIK, AV235988, DUET, Duo, E530005C20RIK, FLJ16443, Gm539, HAPIP, KALIRIN, Kalirin7, KALRN, Pcip10, TRAD
Gene Summary
- Human (8997): Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
- Rat (84009): binds the human huntingtin associated protein Hap1 in vitro; has GDP/GTP exchange factor activity for Rho subfamily GTP-binding proteins [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
axonogenesis, intracellular signaling cascade, nervous system development, protein amino acid phosphorylation, regulation of dendrite development, regulation of Rho protein signal transduction, vesicle-mediated transport
Cellular Components
actin cytoskeleton, cell soma, cytoplasm, cytoskeleton, intracellular, neuron projection, perinuclear region of cytoplasm
Literature References
- 15630019Govek EE, Newey SE, Van Aelst L. The role of the Rho GTPases in neuronal development.Genes Dev 2005 01 1;19(1):1-49
- 16644733Schiller MR, Chakrabarti K, King GF, Schiller NI, Eipper BA, Maciejewski MW. Regulation of RhoGEF Activity by Intramolecular and Intermolecular SH3 Domain Interactions.J Biol Chem 2006 Jul 07;281(27):18774-86
- 15093606Noren NK, Pasquale EB. Eph receptor-ephrin bidirectional signals that target Ras and Rho proteins.Cell Signal 2004 Jun 01;16(6):655-66 View 266 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, guanyl-nucleotide exchange factor activity, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, Rho guanyl-nucleotide exchange factor activity, transferase activity
Protein Domains
carboxy terminal domain, Dbl homology domain, Fibronectin type III domain, guanine nucleotide exchange factor domain, guanyl-nucleotide exchange factor, kinase, pleckstrin homology (PH) domain, protein binding, protein serine/threonine kinase, RhoGEF domain, SH3 domain, spectrin repeat
Subcellular Locations
axons, cell body, cytoplasm, cytosolic fraction, dendrites, dendritic spines, membrane fraction, neurites, perinuclear region, postsynaptic density (PSD) fractions, soluble fraction, synapse
