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GPN1 - GPN-loop GTPase 1
Entrez Gene Name: GPN-loop GTPase 1
Entrez GeneID: Human(11321), Mouse(74254)
Synonyms: 2410004J02Rik, AI449615, ATPBD1A, FLJ51176, GPN1, MBDIN, NTPBP, XAB1

Gene Summary

  • Human (11321): This gene encodes a guanosine triphosphatase enzyme. The encoded protein may play a role in DNA repair and may function in activation of transcription. Alternatively spliced transcript variants have been described. [provided by RefSeq]

Cell Regulation

Regulates:
  • reporter gene
View all 1 in IPA
Regulated by:
  • leptomycin B
View all 1 in IPA
Binds:
  • XPA
  • MBD2
View all 3 in IPA
Role in cell:
  • No Data Available
Disease:
  • No Data Available

Biological Process

No Data Available

Cellular Components

cytoplasm

Literature References

  • 12588985Lembo F, Pero R, Angrisano T, Vitiello C, Iuliano R, Bruni CB, Chiariotti L. MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters.Mol Cell Biol 2003 03 01;23(5):1656-65
  • 11058119Nitta M, Saijo M, Kodo N, Matsuda T, Nakatsu Y, Tamai H, Tanaka K. A novel cytoplasmic GTPase XAB1 interacts with DNA repair protein XPA.Nucleic Acids Res 2000 Nov 1;28(21):4212-8
  • View 57 categorized literature findings and their references in IPA

Molecular Functions

ATP binding, GTP binding, nucleoside-triphosphatase activity, nucleotide binding, protein binding

Pathways

No Data Available

Protein Domains

ATP binding, nucleotide binding, protein binding, transcription regulator

Subcellular Locations

cytoplasm, cytosol, nucleus

IPA Extras