CHRNA5 - cholinergic receptor, nicotinic, alpha 5
Entrez Gene Name: cholinergic receptor, nicotinic, alpha 5
Entrez GeneID: Human(1138)
, Mouse(110835), Rat(25102)
, Mouse(110835), Rat(25102) Synonyms: AChR alpha5, Acra-5, ALPHA5 NACHR, ALPHA5 NICOTINIC RECEPTOR, CHRNA5, LNCR2, MGC124059, MGC124168, nAChR alpha5, sialoprotein
Gene Summary
- Human (1138): Nicotinic acetylcholine receptors (nAChRs), such as CHRNA5, are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be (hetero)pentamers composed of homologous subunits. See MIM 118508 for additional background information on AChRs.[supplied by OMIM]
- Rat (25102): neuronal receptor and ion channel activated by acetylcholine; mediates release of catecholamines into bloodstream [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
behavioral response to nicotine, ion transport, response to nicotine, signal transduction, synaptic transmission, transport
Cellular Components
cell junction, cell soma, dendrite, integral to membrane, membrane, nicotinic acetylcholine-gated receptor-channel complex, plasma membrane, postsynaptic membrane, synapse
Literature References
- 15681842Arredondo J, Chernyavsky AI, Marubio LM, Beaudet AL, Jolkovsky DL, Pinkerton KE, Grando SA. Receptor-Mediated Tobacco Toxicity: Regulation of Gene Expression through {alpha}3{beta}2 Nicotinic Receptor in Oral Epithelial Cells.Am J Pathol 2005 Feb 01;166(2):597-613
- 15155845Salminen O, Murphy KL, McIntosh JM, Drago J, Marks MJ, Collins AC, Grady SR. Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.Mol Pharmacol 2004 Jun 01;65(6):1526-35
- 12695534Salas R, Orr-Urtreger A, Broide RS, Beaudet A, Paylor R, De Biasi M. The Nicotinic Acetylcholine Receptor Subunit alpha5 Mediates Short-Term Effects of Nicotine in Vivo.Mol Pharmacol 2003 May;63(5):1059-66 View 459 categorized literature findings and their references in IPA
Molecular Functions
acetylcholine binding, acetylcholine receptor activity, extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, nicotinic acetylcholine-activated cation-selective channel activity, receptor activity
Protein Domains
acetylcholine binding, acetylcholine receptor, extracellular ligand binding domain, extracellular ligand-gated ion channel, GABA-A receptor, neurotransmitter-gated ion channel ligand binding domain, nicotinic acetylcholine-activated cation-selective channel, transmembrane receptor
