ADORA2A - adenosine A2a receptor
Entrez Gene Name: adenosine A2a receptor
Entrez GeneID: Human(135)
, Mouse(11540), Rat(25369)
, Mouse(11540), Rat(25369) Synonyms: A2A ADENOSINE RECEPTOR, A2AAR, A2AR, AA2AR, Ad2a, ADENO, ADENOSINE A2A RECEPTOR, ADENOSINE RECEPTOR A2A, ADORA2, ADORA2A, Adora2l1, HA2AR, MGC118414, MGC93190, RDC8
Gene Summary
- Human (135): This gene encodes a protein which is one of several receptor subtypes for adenosine. The activity of the encoded protein, a G-protein coupled receptor family member, is mediated by G proteins which activate adenylyl cyclase. The encoded protein is abundant in basal ganglia, vasculature and platelets and it is a major target of caffeine. [provided by RefSeq]
- Rat (25369): plays a role in regulation of blood vessel dilation in the adrenal medulla; regulates sodium excretion [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity, activation of adenylate cyclase activity by G-protein signaling pathway, activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway, adenosine receptor signaling pathway, apoptosis, astrocyte activation, blood circulation, blood coagulation, cAMP biosynthetic process, cell-cell signaling, cellular defense response, central nervous system development, diuresis, eating behavior, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cAMP nucleotide second messenger, induction of apoptosis in response to chemical stimulus, inflammatory response, locomotory behavior, membrane depolarization, natriuresis, negative regulation of alpha-beta T cell activation, negative regulation of caspase activity, negative regulation of cell proliferation, negative regulation of inflammatory response, negative regulation of locomotion, negative regulation of neuron apoptosis, negative regulation of protein kinase activity, negative regulation of vascular permeability, neuron projection morphogenesis, phagocytosis, positive regulation of acetylcholine secretion, positive regulation of cAMP biosynthetic process, positive regulation of circadian sleep/wake cycle, sleep, positive regulation of glutamate secretion, positive regulation of protein secretion, positive regulation of synaptic transmission, GABAergic, positive regulation of synaptic transmission, glutamatergic, prepulse inhibition, regulation of calcium ion transport via voltage-gated calcium channel activity, regulation of excitatory postsynaptic membrane potential, regulation of inhibitory postsynaptic membrane potential, regulation of mitochondrial membrane potential, regulation of norepinephrine secretion, regulation of synaptic plasticity, regulation of transcription, DNA-dependent, response to alkaloid, response to amphetamine, response to caffeine, sensory perception, signal transduction, synaptic transmission, cholinergic, synaptic transmission, dopaminergic, synaptic transmission, glutamatergic, transmembrane receptor protein tyrosine kinase signaling pathway, vasodilation
Cellular Components
asymmetric synapse, axolemma, axon, cell soma, dendrite, endomembrane system, Golgi membrane, integral to membrane, integral to plasma membrane, intermediate filament, membrane, membrane fraction, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic active zone, presynaptic membrane
Literature References
- 15032592Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.Annu Rev Immunol 2004 Jan 01;22:657-82
- 9262401Ledent C, Vaugeois JM, Schiffmann SN, Pedrazzini T, El Yacoubi M, Vanderhaeghen JJ, Costentin J, Heath JK, Vassart G, Parmentier M. Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor.Nature 1997 Aug 14;388(6643):674-8
- 17898087Garcia GE, Truong LD, Li P, Zhang P, Du J, Chen JF, Feng L. Adenosine A2A receptor activation and macrophage-mediated experimental glomerulonephritis.FASEB J 2008 Feb 01;22(2):445-54 View 1834 categorized literature findings and their references in IPA
Molecular Functions
adenosine receptor activity, G-protein coupled, G-protein coupled receptor activity, nonmuscle alpha-actinin binding, protein binding, protein heterodimerization activity, receptor activity, signal transducer activity, type 5 metabotropic glutamate receptor binding
Protein Domains
G-protein coupled adenosine receptor, G-protein coupled receptor, protein binding, protein heterodimerization
Subcellular Locations
axons, cell body, cell surface, cellular membrane, dendrite initial segments, dendrites, membrane fraction, plasma membrane, postsynaptic density, presynaptic terminals, synaptosomes
