PDGFRA - platelet-derived growth factor receptor, alpha polypeptide
Entrez Gene Name: platelet-derived growth factor receptor, alpha polypeptide
Entrez GeneID: Human(5156)
, Mouse(18595), Rat(25267)
, Mouse(18595), Rat(25267) Synonyms: AI115593, APDGFR, CD140A, MGC74795, PDGF ALPHA R, PDGF-ALPHA RECEPTOR, PDGFACE, Pdgfar, PDGFR ALPHA, PDGFR-2, PDGFRA, RHEPDGFRA
Gene Summary
- Human (5156): This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. [provided by RefSeq]
- Rat (25267): acts as a receptor tyrosine kinase for PDGF; may play a role in glial cell generation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
anatomical structure morphogenesis, cell activation, extracellular matrix organization, face morphogenesis, gliogenesis, in utero embryonic development, inner ear development, lung development, male genitalia development, odontogenesis of dentine-containing tooth, organ morphogenesis, palate development, peptidyl-tyrosine phosphorylation, platelet-derived growth factor receptor signaling pathway, positive regulation of cell migration, positive regulation of cell proliferation, positive regulation of DNA replication, positive regulation of fibroblast proliferation, protein amino acid autophosphorylation, protein amino acid phosphorylation, response to cytokine stimulus, response to estradiol stimulus, response to estrogen stimulus, response to hormone stimulus, response to hyperoxia, response to inorganic substance, response to organic substance, skeletal system morphogenesis, transmembrane receptor protein tyrosine kinase signaling pathway, wound healing
Literature References
- 9442882Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases.Annu Rev Cell Dev Biol 1997;13:513-609
- 7888178van der Geer P, Hunter T, Lindberg RA. Receptor protein-tyrosine kinases and their signal transduction pathways.Annu Rev Cell Biol 1994;10:251-337
- 7688944Fantl WJ, Johnson DE, Williams LT. Signalling by receptor tyrosine kinases.Annu Rev Biochem 1993;62:453-81 View 1867 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinase activity, nucleotide binding, platelet-derived growth factor alpha-receptor activity, platelet-derived growth factor binding, platelet-derived growth factor receptor binding, protein dimerization activity, protein heterodimerization activity, protein homodimerization activity, protein kinase activity, protein tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity, vascular endothelial growth factor receptor activity
Protein Domains
extracellular domain, immunoglobulin domain, intracellular domain, juxtamembrane domain, kinase, platelet-derived growth factor receptor alpha, platelet-derived growth factor receptor binding, protein heterodimerization, protein homodimerization, protein-tyrosine kinase, transmembrane domain
Subcellular Locations
axon initial segments, cell body, cell surface, cellular membrane, cytoplasm, dendrites, detergent-soluble fraction, plasma membrane
