AURKB - aurora kinase B
Entrez Gene Name: aurora kinase B
Entrez GeneID: Human(9212)
, Mouse(20877), Rat(114592)
, Mouse(20877), Rat(114592) Synonyms: AIK2, AIM-1, AIRK2, AL022959, ARK2, AurB, AURKB, AURORA B, IPL1, Serine/threonine kinase 5, STK-1, STK12, STK5, YRK
Gene Summary
- Human (9212): Chromosomal segregation during mitosis as well as meiosis is regulated by kinases and phosphatases. The Aurora kinases associate with microtubules during chromosome movement and segregation. Aurora kinase B localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers, and Aurora kinase A (MIM 603072) localizes to centrosomes (Lampson et al., 2004 [PubMed 14767480]).[supplied by OMIM]
- Rat (114592): kinase; involved in proper progression of cytokinesis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle, cell division, cytokinesis, mitosis, protein amino acid phosphorylation
Literature References
- 17483322Hayama S, Daigo Y, Yamabuki T, Hirata D, Kato T, Miyamoto M, Ito T, Tsuchiya E, Kondo S, Nakamura Y. Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis.Cancer Res 2007 May 01;67(9):4113-22
- 14722118Yasui Y, Urano T, Kawajiri A, Nagata K, Tatsuka M, Saya H, Furukawa K, Takahashi T, Izawa I, Inagaki M. Autophosphorylation of a newly identified site of aurora-B is indispensable for cytokinesis.J Biol Chem 2004 Mar 26;279(13):12997-3003
- 12925766Honda R, Korner R, Nigg EA. Exploring the Functional Interactions between Aurora B, INCENP, and Survivin in Mitosis.Mol Biol Cell 2003 Aug;14(8):3325-41 View 376 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, kinase activity, magnesium ion binding, metal ion binding, nucleotide binding, protein binding, protein kinase activity, protein serine/threonine kinase activity, transferase activity
Protein Domains
catalytic domain, DNA binding, kinase, N-methyltransferase, protein binding, Protein kinase, protein serine/threonine kinase, SH3 domain
Subcellular Locations
central spindle, centromeres, centromeric region, chromosomes, cleavage furrow, contractile rings, cytoplasmic fraction, kinetochores, metaphase plate, midbody, nuclear foci, nuclear scaffolds, nucleus, pericentric heterochromatin
