FGF10 - fibroblast growth factor 10
Entrez Gene Name: fibroblast growth factor 10
Entrez GeneID: Human(2255)
, Mouse(14165), Rat(25443)
, Mouse(14165), Rat(25443) Synonyms: BB213776, FGF10
Gene Summary
- Human (2255): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq]
- Rat (25443): binds the KGFR receptor, a splice variant of FGFR-2; may contribute to tissue regeneration and angiogenesis after acute pancreatitis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
alveolus development, angiogenesis, blood vessel morphogenesis, blood vessel remodeling, branching morphogenesis of a tube, cell differentiation, cell-cell signaling, chemotaxis, determination of left/right symmetry, embryonic gut development, embryonic limb morphogenesis, embryonic pattern specification, epidermis development, fibroblast growth factor receptor signaling pathway, induction of an organ, induction of positive chemotaxis, inner ear morphogenesis, keratinocyte proliferation, lacrimal gland development, limb development, limb morphogenesis, lung development, negative regulation of cell differentiation, negative regulation of cell proliferation, organ morphogenesis, pancreas development, positive regulation of cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of receptor-mediated endocytosis, positive regulation of urothelial cell proliferation, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of Wnt receptor signaling pathway, protein import into nucleus, translocation, regulation of transcription, response to protein stimulus, response to stress, signal transduction, smooth muscle cell differentiation, spleen development, tissue regeneration
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 18535112Omoto Y. Estrogen Receptor-{alpha} Signaling in Growth of the Ventral Prostate: Comparison of Neonatal Growth and Postcastration Regrowth.Endocrinology 2008 Sep 01;149(9):4421-7
- 11959839Sakaue H, Konishi M, Ogawa W, Asaki T, Mori T, Yamasaki M, Takata M, Ueno H, Kato S, Kasuga M, Itoh N. Requirement of fibroblast growth factor 10 in development of white adipose tissue.Genes Dev 2002 Apr 15;16(8):908-12 View 576 categorized literature findings and their references in IPA
Molecular Functions
chemoattractant activity, fibroblast growth factor receptor binding, growth factor activity, heparin binding, protein binding
Protein Domains
fibroblast growth factor receptor binding, growth factor, heparin binding, protein binding
