ADRB3 - adrenergic, beta-3-, receptor
Entrez Gene Name: adrenergic, beta-3-, receptor
Entrez GeneID: Human(155)
, Mouse(11556), Rat(25645)
, Mouse(11556), Rat(25645) Synonyms: ADRB, ADRB3, B3 ar, BETA3 ADRENERGIC RECEPTOR, BETA3 ADRENOCEPTOR, BETA3-AR, FLJ99960
Gene Summary
- Human (155): The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq]
- Rat (25645): binds BRL373 and norepenephrine; may play a role in the adrenergic signaling pathway [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity by G-protein signaling pathway, brown fat cell differentiation, carbohydrate metabolic process, desensitization of G-protein coupled receptor protein signaling pathway by arrestin, diet induced thermogenesis, energy reserve metabolic process, G-protein coupled receptor protein signaling pathway, generation of precursor metabolites and energy, heat generation, negative regulation of multicellular organism growth, positive regulation of MAPKKK cascade, receptor-mediated endocytosis, response to cold, signal transduction, vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
Cellular Components
integral to membrane, integral to plasma membrane, membrane, membrane fraction, plasma membrane, receptor complex
Literature References
- 9858769Herdegen T, Leah JD. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.Brain Res Brain Res Rev 1998 Dec;28(3):370-490
- 17293562Deupree JD, Reed AL, Bylund DB. Differential effects of the tricyclic antidepressant desipramine on the density of adrenergic receptors in juvenile and adult rats.J Pharmacol Exp Ther 2007 May 01;321(2):770-6
- 15665039Chernogubova E, Hutchinson DS, Nedergaard J, Bengtsson T. {alpha}1- and {beta}1-Adrenoceptor Signaling Fully Compensates for {beta}3-Adrenoceptor Deficiency in Brown Adipocyte Norepinephrine-Stimulated Glucose Uptake.Endocrinology 2005 May 01;146(5):2271-84 View 867 categorized literature findings and their references in IPA
Molecular Functions
adrenoceptor activity, beta-3 adrenergic receptor binding, beta-adrenergic receptor activity, beta3-adrenergic receptor activity, epinephrine binding, G-protein coupled receptor activity, norepinephrine binding, protein binding, protein homodimerization activity, receptor activity, signal transducer activity
Protein Domains
beta3-adrenergic receptor, G-protein coupled receptor, intracellular domain, protein homodimerization
