GABRB2 - gamma-aminobutyric acid (GABA) A receptor, beta 2
Entrez Gene Name: gamma-aminobutyric acid (GABA) A receptor, beta 2
Entrez GeneID: Human(2561)
, Mouse(14401), Rat(25451)
, Mouse(14401), Rat(25451) Synonyms: AI834970, C030002O17RIK, C030021G16Rik, GABA A RECEPTOR B2, Gaba A receptor beta-2, GABA A RECEPTOR SUBUNIT BETA2, GABA-A, Gabrab2, GABRB2, GARB2, MGC119386, MGC119388, MGC119389
Gene Summary
- Human (2561): The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq]
- Rat (25451): subunit of GABA-A receptors, which induce inhibitory postsynaptic currents; mediates desentization [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Regulates:
| Role in cell:
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Biological Process
gamma-aminobutyric acid signaling pathway, ion transport, synaptic transmission, transport
Cellular Components
cell junction, integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic membrane, synapse
Literature References
- 17012619Sancar F, Ericksen SS, Kucken AM, Teissére JA, Czajkowski C. Structural Determinants for High-Affinity Zolpidem Binding to GABA-A receptors.Mol Pharmacol 2007 Jan 01;71(1):38-46
- 12818177Wang Q, Liu L, Pei L, Ju W, Ahmadian G, Lu J, Wang Y, Liu F, Wang YT. Control of synaptic strength, a novel function of Akt.Neuron 2003 Jun 19;38(6):915-28
- 16567807Serantes R, Arnalich F, Figueroa M, Salinas M, Andrés-Mateos E, Codoceo R, Renart J, Matute C, Cavada C, Cuadrado A, Montiel C. Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy.J Biol Chem 2006 May 26;281(21):14632-43 View 427 categorized literature findings and their references in IPA
Molecular Functions
chloride channel activity, chloride ion binding, extracellular ligand-gated ion channel activity, GABA-A receptor activity, inhibitory extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, protein binding, receptor activity
Protein Domains
extracellular ligand binding domain, GABA-A receptor, inhibitory extracellular ligand-gated ion channel, intracellular domain, intracellular loop, ion channel, neurotransmitter-gated ion channel ligand binding domain, protein binding
