CYP19A1 - cytochrome P450, family 19, subfamily A, polypeptide 1
Entrez Gene Name: cytochrome P450, family 19, subfamily A, polypeptide 1
Entrez GeneID: Human(1588)
, Mouse(13075), Rat(25147)
, Mouse(13075), Rat(25147) Synonyms: Ar, ArKO, ARO, ARO1, AROMATASE, CPV1, CYAR, CYP19, Cyp19a, CYP19A1, CYP19P1, Int-5, MGC104309, MGC124251, MGC124252, P-450AROM, p450 aromatase
Gene Summary
- Human (1588): This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq]
- Rat (25147): catalyzes end-step estrogen formation from androgens and aromatization of testosterone to estradiol [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
estrogen biosynthetic process, oxidation reduction, regulation of synapse structure and activity, steroid biosynthetic process
Cellular Components
cytoplasm, dendritic spine, endoplasmic reticulum, membrane, membrane fraction, nerve terminal, synaptic vesicle
Literature References
- 18083712Subbaramaiah K, Hudis C, Chang SH, Hla T, Dannenberg AJ. EP2 and EP4 Receptors Regulate Aromatase Expression in Human Adipocytes and Breast Cancer Cells: EVIDENCE OF A BRCA1 AND p300 EXCHANGE.J Biol Chem 2008 Feb 08;283(6):3433-44
- 17875734Chen D, Reierstad S, Lin Z, Lu M, Brooks C, Li N, Innes J, Bulun SE. Prostaglandin E2 Induces Breast Cancer Related Aromatase Promoters via Activation of p38 and c-Jun NH2-Terminal Kinase in Adipose Fibroblasts.Cancer Res 2007 Sep 15;67(18):8914-22
- 17804753Sirianni R, Chimento A, Malivindi R, Mazzitelli I, Andò S, Pezzi V. Insulin-Like Growth Factor-I, Regulating Aromatase Expression through Steroidogenic Factor 1, Supports Estrogen-Dependent Tumor Leydig Cell Proliferation.Cancer Res 2007 Sep 01;67(17):8368-77 View 1774 categorized literature findings and their references in IPA
Molecular Functions
aromatase activity, electron carrier activity, heme binding, iron ion binding, metal ion binding, monooxygenase activity, oxidoreductase activity, oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen, oxygen binding
Subcellular Locations
axon terminals, cell body, cellular membrane, cytoplasm, dendrites, dendritic spines, endoplasmic reticulum, endoplasmic reticulum membrane, flagella, Golgi region, microsomal fraction, perinuclear region, postsynaptic density, postsynaptic region, presynaptic regions, residual bodies, rough endoplasmatic reticulum, synaptic vesicles
