ABCB1 - ATP-binding cassette, sub-family B (MDR/TAP), member 1
Entrez Gene Name: ATP-binding cassette, sub-family B (MDR/TAP), member 1
Entrez GeneID: Human(5243)
, Mouse(18671), Rat(170913)
, Mouse(18671), Rat(170913) Synonyms: ABC20, ABCB1, Abcb1a, Abcb4, CD243, CLCS, EVI32, GP170, MDR, mdr-3, MDR1, Mdr1a, MDR1B, MGC163296, P-GLYCOPROTEIN, P-GP, Pgy-3, PGY1
Gene Summary
- Human (5243): The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq]
- Mouse (18671): The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq]
- Rat (170913): ATP-binding cassette (ABC) multiple drug transporter P-glycoprotein that is activated during liver regeneration and hepatocarcinogenesis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Cellular Components
cell surface, integral to membrane, intercellular canaliculus, membrane, membrane fraction
Literature References
- 12045106Borst P, Elferink RO. Mammalian ABC transporters in health and disease.Annu Rev Biochem 2002;71:537-92
- 19047049Bourguignon LY, Xia W, Wong G. Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates {beta}-Catenin Signaling and NF{kappa}B-specific Transcription Activity Leading to MDR1 and Bcl-xL Gene Expression and Chemoresistance in Breast Tumor Cells.J Biol Chem 2009 Jan 30;284(5):2657-71
- 16388406Sakaeda T, Fujino H, Komoto C, Kakumoto M, Jin JS, Iwaki K, Nishiguchi K, Nakamura T, Okamura N, Okumura K. Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport.Pharm Res 2006 Mar 01;23(3):506-12 View 2093 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATPase activity, ATPase activity, coupled, ATPase activity, coupled to transmembrane movement of substances, hydrolase activity, nucleoside-triphosphatase activity, nucleotide binding, protein binding, transporter activity, xenobiotic-transporting ATPase activity
Protein Domains
ATP binding, ATPase activity, coupled, linker domain, nucleotide binding fold domain, nucleotide-binding domain, protein binding, transporter
Subcellular Locations
apical membrane, brush border, cell surface, cellular membrane, cytoplasm, endoplasmic reticulum, Golgi apparatus, membrane fraction, membrane rafts, membrane surface, pH resistant lipid raft fraction, plasma membrane
