GLRX2 - glutaredoxin 2
Entrez Gene Name: glutaredoxin 2
Entrez GeneID: Human(51022)
, Mouse(69367), Rat(114022)
, Mouse(69367), Rat(114022) Synonyms: 1700010P22Rik, AI645710, bA101E13.1, CGI-133, GLRX2, GRX2
Gene Summary
- Human (51022): Glutaredoxins (e.g., GLRX; MIM 600443) are a family of glutathione-dependent hydrogen donors that participate in a variety of cellular redox reactions.[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Binds:
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Biological Process
apoptosis, cell differentiation, cell redox homeostasis, DNA protection, electron transport chain, glutathione metabolic process, protein thiol-disulfide exchange, redox signal response, regulation of signal transduction, regulation of transcription, response to hydrogen peroxide, response to organic substance, response to temperature stimulus, transport
Literature References
- 11297543Lundberg M, Johansson C, Chandra J, Enoksson M, Jacobsson G, Ljung J, Johansson M, Holmgren A. Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms.J Biol Chem 2001 Jul 13;276(28):26269-75
- 12732627Wang X, Phelan SA, Forsman-Semb K, Taylor EF, Petros C, Brown A, Lerner CP, Paigen B. Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress.J Biol Chem 2003 07 4;278(27):25179-90
- 14676218Johansson C, Lillig CH, Holmgren A. Human mitochondrial glutaredoxin reduces s-glutathionylated proteins with high affinity accepting electrons from either glutathione or thioredoxin reductase.J Biol Chem 2004 Feb 27;279(9):7537-43 View 66 categorized literature findings and their references in IPA
Molecular Functions
2 iron, 2 sulfur cluster binding, arsenate reductase (glutaredoxin) activity, electron carrier activity, glutathione disulfide oxidoreductase activity, iron ion binding, iron-sulfur cluster binding, metal ion binding, protein disulfide oxidoreductase activity, transferase activity
Protein Domains
active site, Arsenate reductase (glutaredoxin), electron donor, enzyme, glutathione disulfide oxidoreductase, thiol-disulfide exchange intermediate
