ADORA1 - adenosine A1 receptor
Entrez Gene Name: adenosine A1 receptor
Entrez GeneID: Human(134)
, Mouse(11539), Rat(29290)
, Mouse(11539), Rat(29290) Synonyms: A1 ADENOSINE RECEPTOR, A1-AR, A1R, AA1R, Ad1, ADENOSINE A1 RECEPTOR, ADORA1, AI848715, BB176431, RDC7, Ri
Gene Summary
- Human (134): The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq]
- Rat (29290): inhibits adenylyl cyclase activity; plays a role in regulation of arterial pressure, heart rate, and sodium excretion [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPKK activity, cell-cell signaling, G-protein coupled receptor protein signaling pathway, induction of apoptosis by extracellular signals, inflammatory response, inhibition of adenylate cyclase activity by G-protein signaling, natriuresis, negative regulation of apoptosis, negative regulation of cell proliferation, negative regulation of circadian sleep/wake cycle, sleep, negative regulation of glutamate secretion, negative regulation of heart contraction, negative regulation of hormone secretion, negative regulation of inflammatory response, negative regulation of leukocyte migration, negative regulation of lipid catabolic process, negative regulation of mucus secretion, negative regulation of synaptic transmission, GABAergic, negative regulation of synaptic transmission, glutamatergic, negative regulation of vasodilation, nervous system development, phagocytosis, positive regulation of blood pressure, positive regulation of nucleoside transport, positive regulation of peptide secretion, positive regulation of potassium ion transport, positive regulation of protein amino acid dephosphorylation, regulation of excitatory postsynaptic membrane potential, regulation of respiratory gaseous exchange by neurological process, regulation of synaptic plasticity, regulation of vasodilation, signal transduction, temperature homeostasis
Cellular Components
asymmetric synapse, axolemma, basolateral plasma membrane, cell soma, dendrite, endomembrane system, endoplasmic reticulum, integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic active zone, presynaptic membrane, terminal button
Literature References
- 15032592Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, Ohta A, Thiel M. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors.Annu Rev Immunol 2004 Jan 01;22:657-82
- 17646043Schiffmann SN, Fisone G, Moresco R, Cunha RA, Ferré S. Adenosine A2A receptors and basal ganglia physiology.Prog Neurobiol 2007 Dec 01;83(5):277-92
- 17609415Pingle SC, Jajoo S, Mukherjea D, Sniderhan LF, Jhaveri KA, Marcuzzi A, Rybak LP, Maggirwar SB, Ramkumar V. Activation of the Adenosine A1 Receptor Inhibits HIV-1 Tat-Induced Apoptosis by Reducing Nuclear Factor-{kappa}B Activation and Inducible Nitric-Oxide Synthase.Mol Pharmacol 2007 Oct 01;72(4):856-67 View 1032 categorized literature findings and their references in IPA
Molecular Functions
adenosine receptor activity, G-protein coupled, G-protein beta/gamma-subunit binding, G-protein coupled receptor activity, heterotrimeric G-protein binding, protein heterodimerization activity, purine nucleoside binding, receptor activity, signal transducer activity
Protein Domains
A1 G-protein coupled adenosine receptor, G-protein coupled adenosine receptor, G-protein coupled receptor, protein heterodimerization, third intracellular loop
Subcellular Locations
axons, basolateral membrane, caveolae, caveolae fraction, cell body, cell surface, cellular membrane, cytoplasm, dendrites, endoplasmic reticulum, membrane fraction, membrane processes, perinuclear region, plasma membrane, presynaptic terminals, synapse, synaptosomes
