CALB1 - calbindin 1, 28kDa
Entrez Gene Name: calbindin 1, 28kDa
Entrez GeneID: Human(793)
, Mouse(12307), Rat(83839)
, Mouse(12307), Rat(83839) Synonyms: Brain-2, Cabp-d28k, CaBP28K, Cad28k, CALB, CALB1, CALBINDIN D, CALBINDIN-28K, CALBINDIN-D28K, Calbindin1, CB, MGC93326
Gene Summary
- Human (793): Calbindin is a calcium-binding protein belonging to the troponin C superfamily. It was originally described as a 27-kD protein induced by vitamin D in the duodenum of the chick. In the brain, its synthesis is independent of vitamin-D-derived hormones. Calbindin contains 4 active calcium-binding domains, and 2 modified domains that presumably have lost their calcium-binding capacity. The neurons in brains of patients with Huntington disease are calbindin-depleted. [provided by RefSeq]
- Rat (83839): binds calcium; activity is vitamin D dependent [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
learning or memory, locomotory behavior, regulation of synaptic plasticity, vitamin D metabolic process
Literature References
- 15907476Ballas N, Grunseich C, Lu DD, Speh JC, Mandel G. REST and Its Corepressors Mediate Plasticity of Neuronal Gene Chromatin throughout Neurogenesis.Cell 2005 May 20;121(4):645-57
- 15456794Zheng W, Xie Y, Li G, Kong J, Feng JQ, Li YC. Critical role of calbindin-d28k in calcium homeostasis revealed by mice lacking both vitamin d receptor and calbindin-d28k.J Biol Chem 2004 Dec 10;279(50):52406-13
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363 View 1338 categorized literature findings and their references in IPA
Subcellular Locations
axons, basolateral membrane, cell body, cytoplasm, cytosol, cytosolic fraction, dendrites, dendritic trees, mossy fibers, nerve ending, nucleus, perinuclear region
