KCNJ1 - potassium inwardly-rectifying channel, subfamily J, member 1
Entrez Gene Name: potassium inwardly-rectifying channel, subfamily J, member 1
Entrez GeneID: Human(3758)
, Mouse(56379), Rat(24521)
, Mouse(56379), Rat(24521) Synonyms: Kcnj, KCNJ1, KIR1.1, ROMK, ROMK-2, ROMK1
Gene Summary
- Human (3758): Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Rat (24521): potassium channel involved in K+ secretion in the renal distal nephron [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Cellular Components
integral to membrane, membrane, plasma membrane, voltage-gated potassium channel complex
Literature References
- 14608358Kahle KT, Wilson FH, Leng Q, Lalioti MD, O'Connell AD, Dong K, Rapson AK, MacGregor GG, Giebisch G, Hebert SC, Lifton RP. WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.Nat Genet 2003 Dec 01;35(4):372-6
- 17314327Schmidt C, Höcherl K, Schweda F, Kurtz A, Bucher M. Regulation of renal sodium transporters during severe inflammation.J Am Soc Nephrol 2007 Apr 01;18(4):1072-83
- 14604981Yoo D, Flagg TP, Olsen O, Raghuram V, Foskett JK, Welling PA. Assembly and Trafficking of a Multiprotein ROMK (Kir 1.1) Channel Complex by PDZ Interactions.J Biol Chem 2004 Feb 20;279(8):6863-73 View 197 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATP-activated inward rectifier potassium channel activity, inward rectifier potassium channel activity, ion channel activity, nucleotide binding, peptide binding, potassium ion binding, protein binding, voltage-gated ion channel activity
Protein Domains
ATP-activated inward rectifier potassium channel, cytoplasmic domain, inward rectifier potassium channel, ion channel, peptide binding, protein binding
Subcellular Locations
apical membrane, cell periphery, cell surface, cellular membrane, endoplasmic reticulum, Golgi apparatus, plasma membrane
