AXIN1 - axin 1
Entrez Gene Name: axin 1
Entrez GeneID: Human(8312)
, Mouse(12005), Rat(79257)
, Mouse(12005), Rat(79257) Synonyms: AI316800, AXIN, AXIN FORM I, AXIN1, Fu, fused, Kb, Ki, kinky, knobbly, MGC132911, MGC52315
Gene Summary
- Human (8312): This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin (cadherin-associated protein), beta 1, 88kDa, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, multicellular organismal development, negative regulation of cell cycle, negative regulation of Wnt receptor signaling pathway, oocyte axis specification, positive regulation of JNK cascade, positive regulation of peptidyl-serine phosphorylation, positive regulation of peptidyl-threonine phosphorylation, positive regulation of protein ubiquitination, protein catabolic process, sensory perception of sound, Wnt receptor signaling pathway, Wnt receptor signaling pathway through beta-catenin
Cellular Components
beta-catenin destruction complex, cytoplasm, cytoplasmic membrane-bounded vesicle, cytoplasmic vesicle, cytosol, intracellular, lateral plasma membrane, nucleus, synapse
Literature References
- 16815997Chen HJ, Lin CM, Lin CS, Perez-Olle R, Leung CL, Liem RK. The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.Genes Dev 2006 Jul 15;20(14):1933-45
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 15526030Rui Y, Xu Z, Lin S, Li Q, Rui H, Luo W, Zhou HM, Cheung PY, Wu Z, Ye Z, Li P, Han J, Lin SC. Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation.EMBO J 2004 Nov 24;23(23):4583-94 View 1172 categorized literature findings and their references in IPA
Molecular Functions
armadillo repeat domain binding, beta-catenin binding, I-SMAD binding, phosphate binding, protein binding, protein homodimerization activity, signal transducer activity
- Ephrin Receptor Signaling
- Molecular Mechanisms of Cancer
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Wnt/β-catenin Signaling
- Basal Cell Carcinoma Signaling
- Human Embryonic Stem Cell Pluripotency
- Factors Promoting Cardiogenesis in Vertebrates
- Colorectal Cancer Metastasis Signaling
- Endometrial Cancer Signaling
- Germ Cell-Sertoli Cell Junction Signaling
Protein Domains
beta-catenin binding, beta-catenin binding domain, carboxy terminal domain, DIX domain, GSK-3beta binding domain, phosphate binding, protein binding, protein homodimerization, RGS domain
Subcellular Locations
cell periphery, cytoplasm, cytoplasmic vesicles, cytosol, lateral cell-cell contacts, nuclear envelope, nucleus, perinuclear region, plasma membrane, vesicles
