P2RX1 - purinergic receptor P2X, ligand-gated ion channel, 1
Entrez Gene Name: purinergic receptor P2X, ligand-gated ion channel, 1
Entrez GeneID: Human(5023)
, Mouse(18436), Rat(25505)
, Mouse(18436), Rat(25505) Synonyms: AI323649, BB122383, P2RX1, P2x, P2X1, P2x1 receptor, P2XMR, PDCD3, RP-2
Gene Summary
- Human (5023): The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill. [provided by RefSeq]
- Rat (25505): ligand-gated cation-selective ion channel with relatively high calcium permeability; activated by ATP and may be involved in synaptic transmission [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
activation of caspase activity, apoptosis, ceramide biosynthetic process, death, insemination, ion transport, platelet activation, positive regulation of ion transport, protein heterooligomerization, protein homooligomerization, regulation of action potential in neuron, regulation of blood pressure, regulation of calcium ion transport, regulation of smooth muscle contraction, regulation of vascular smooth muscle contraction, regulation of vasoconstriction, response to ATP, response to organic substance, response to stimulus, serotonin secretion by platelet, signal transduction, synaptic transmission, glutamatergic, transport, vasoconstriction
Cellular Components
external side of cell outer membrane, integral to membrane, integral to plasma membrane, membrane, membrane raft, plasma membrane, postsynaptic membrane, protein complex, synaptosome
Literature References
- 17895406Dubyak GR. Go It Alone No More P2X7 Joins the Society of Heteromeric ATP-Gated Receptor Channels.Mol Pharmacol 2007 Dec 01;72(6):1402-5
- 17428985Roberts JA, Evans RJ. Cysteine substitution mutants give structural insight and identify ATP binding and activation sites at P2X receptors.J Neurosci 2007 Apr 11;27(15):4072-82
- 12913094Hechler B, Lenain N, Marchese P, Vial C, Heim V, Freund M, Cazenave JP, Cattaneo M, Ruggeri ZM, Evans R, Gachet C. A role of the fast ATP-gated P2X1 cation channel in thrombosis of small arteries in vivo.J Exp Med 2003 Aug 18;198(4):661-7 View 170 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATP-gated cation channel activity, calcium channel activity, cation channel activity, drug binding, ion channel activity, protein binding, protein heterodimerization activity, protein homodimerization activity, purinergic nucleotide receptor activity, receptor activity, zinc ion binding
Protein Domains
ATP binding, ATP-gated cation channel, calcium channel, cation channel, drug binding, ion channel, protein binding, purinergic nucleotide receptor, zinc ion binding
