E2F3 - E2F transcription factor 3
Entrez Gene Name: E2F transcription factor 3
Entrez GeneID: Human(1871)
, Mouse(13557), Rat(291105)
, Mouse(13557), Rat(291105) Synonyms: DKFZp686C18211, E2F3, E2f3 predicted, E2F3A, KIAA0075, MGC104598, mKIAA0075, RGD1561600
Gene Summary
- Human (1871): The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F2, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
cell cycle, positive regulation of cell proliferation, positive regulation of transcription, DNA-dependent, regulation of transcription, DNA-dependent, transcription, transcription initiation from RNA polymerase II promoter
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 12411495Schlisio S, Halperin T, Vidal M, Nevins JR. Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function.EMBO J 2002 Nov 1;21(21):5775-5786
- 11799066Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis.Genes Dev 2002 Jan 15;16(2):235-44 View 1331 categorized literature findings and their references in IPA
Molecular Functions
DNA binding, protein binding, transcription activator activity, transcription factor activity
Protein Domains
cyclin recognition motif, DNA binding, marked box, protein binding, transcription factor, transcription regulator, transcriptional activator
