GABBR2 - gamma-aminobutyric acid (GABA) B receptor, 2
Entrez Gene Name: gamma-aminobutyric acid (GABA) B receptor, 2
Entrez GeneID: Human(9568)
, Mouse(242425), Rat(83633)
, Mouse(242425), Rat(83633) Synonyms: FLJ36928, GABA B2, GABABR2, GABBR2, GB2, GBR2, Gm425, GPR51, GPRC3B, HG20, HRIHFB2099
Gene Summary
- Human (9568): B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]
- Rat (83633): combines with GABA-B1 to form functional GABA-B receptors; inhibits high voltage activated calcium ion channels [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
G-protein coupled receptor protein signaling pathway, gamma-aminobutyric acid signaling pathway, negative regulation of adenylate cyclase activity, signal transduction, synaptic transmission
Cellular Components
cell junction, cytoplasm, integral to membrane, integral to plasma membrane, membrane, neuron projection, plasma membrane, postsynaptic membrane, synapse
Literature References
- 9872744Kuner R, Köhr G, Grünewald S, Eisenhardt G, Bach A, Kornau HC. Role of heteromer formation in GABAB receptor function.Science 1999 Jan 1;283(5398):74-7
- 9872317Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, Beck P, Mosbacher J, Bischoff S, Kulik A, Shigemoto R, Karschin A, Bettler B. GABA(B)-receptor subtypes assemble into functional heteromeric complexes.Nature 1998 Dec 17;396(6712):683-7
- 16033418Bauer A, Zilles K, Matusch A, Holzmann C, Riess O, von Hörsten S. Regional and subtype selective changes of neurotransmitter receptor density in a rat transgenic for the Huntington's disease mutation.J Neurochem 2005 Aug 01;94(3):639-50 View 304 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, GABA-B receptor activity, protein binding, receptor activity, signal transducer activity
Protein Domains
carboxy terminal domain, extracellular ligand binding domain, G-protein coupled receptor, GABA-B receptor, protein binding
Subcellular Locations
cell body, cell surface, cellular membrane, cytoplasm, cytoplasmic face of plasma membrane, cytoplasmic foci, cytosol, endoplasmic reticulum-rich vesicle fraction, Golgi-enriched fraction, membrane fraction, membrane processes, neurites, nucleus, plasma membrane, synaptosomes
