SH2D1B - SH2 domain containing 1B
Entrez Gene Name: SH2 domain containing 1B
Entrez GeneID: Human(117157)
, Mouse(26904), Rat(501869)
, Mouse(26904), Rat(501869) Synonyms: EAT-2A, EAT2, RGD1563935, SH2D1B, Sh2d1b1
Gene Summary
- Human (117157): By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
natural killer cell inhibitory signaling pathway, negative regulation of interferon-gamma production, negative regulation of natural killer cell mediated cytotoxicity, negative regulation of peptidyl-tyrosine phosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of peptidyl-tyrosine phosphorylation
Literature References
- 11689425Morra M, Lu J, Poy F, Martin M, Sayos J, Calpe S, Gullo C, Howie D, Rietdijk S, Thompson A, Coyle AJ, Denny C, Yaffe MB, Engel P, Eck MJ, Terhorst C. Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells.EMBO J 2001 Nov 1;20(21):5840-52
- 12458214Li C, Iosef C, Jia CY, Han VK, Li SS. Dual functional roles for the XLP syndrome gene product SAP/SH2D1A in signaling through the SLAM family of immune receptors.J Biol Chem 2003 02 7;278(6):3852-9
- 17599905Clarkson NG, Simmonds SJ, Puklavec MJ, Brown MH. Direct and Indirect Interactions of the Cytoplasmic Region of CD244 (2B4) in Mice and Humans with FYN Kinase.J Biol Chem 2007 Aug 31;282(35):25385-94 View 91 categorized literature findings and their references in IPA
