G3BP1 - GTPase activating protein (SH3 domain) binding protein 1
Entrez Gene Name: GTPase activating protein (SH3 domain) binding protein 1
Entrez GeneID: Human(10146)
, Mouse(27041), Rat(171092)
, Mouse(27041), Rat(171092) Synonyms: AI849976, B430204O07, C87777, G3BP, G3BP1, HDH-VIII, KIAA4115, MGC111040, mKIAA4115, Ras gtpase activating protein sh3 domain binding, Ras gtpase activating sh3 domain binding, RGD1310666, RP23-336J1.4
Gene Summary
- Human (10146): This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq]
- Rat (171092): mouse homolog may play a role in the RNA-protein complex mediated transport of tau mRNA from neuronal cell body to the distal axon in developing neurons [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Role in cell:
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Literature References
- 11888885Barnes CJ, Li F, Mandal M, Yang Z, Sahin AA, Kumar R. Heregulin induces expression, ATPase activity, and nuclear localization of G3BP, a Ras signaling component, in human breast tumors.Cancer Res 2002 Mar 1;62(5):1251-5
- 11439350Soncini C, Berdo I, Draetta G. Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.Oncogene 2001 Jun 28;20(29):3869-79
- 8649363Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B. A Ras-GTPase-activating protein SH3-domain-binding protein.Mol Cell Biol 1996 Jun 1;16(6):2561-9 View 125 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATP-dependent DNA helicase activity, ATP-dependent RNA helicase activity, DNA binding, endonuclease activity, helicase activity, hydrolase activity, nuclease activity, nucleic acid binding, nucleotide binding, protein binding, RNA binding
Protein Domains
ATP dependent DNA helicase, ATP dependent RNA helicase, enzyme, NTF2 domain, protein binding, RNA recognition motif
Subcellular Locations
cytoplasm, detergent resistant lipid raft fraction, nucleus, polyribosome fractions, stress granule
