P2RY12 - purinergic receptor P2Y, G-protein coupled, 12
Entrez Gene Name: purinergic receptor P2Y, G-protein coupled, 12
Entrez GeneID: Human(64805)
, Mouse(70839), Rat(64803)
, Mouse(70839), Rat(64803) Synonyms: 2900079B22Rik, 4921504D23Rik, ADP RECEPTOR, ADPG-R, HORK3, P2cyc, P2RY12, P2T(AC), P2TAC, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, P2y12 Receptor, SP1999
Gene Summary
- Human (64805): The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene. [provided by RefSeq]
- Rat (64803): receptor activated by platelet ADP release; mediates adenylate cyclase inhibition and is a target of antithrombotic drugs [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cAMP nucleotide second messenger, hemostasis, negative regulation of adenylate cyclase activity, platelet activation, positive regulation of ion transport, protein kinase B signaling cascade, signal transduction
Literature References
- 16835302Savi P, Zachayus JL, Delesque-Touchard N, Labouret C, Hervé C, Uzabiaga MF, Pereillo JM, Culouscou JM, Bono F, Ferrara P, Herbert JM. The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts.Proc Natl Acad Sci U S A 2006 Jul 18;103(29):11069-74
- 15850493Kokkola T, Savinainen JR, Mönkkönen KS, Retamal MD, Laitinen JT. S-nitrosothiols modulate G protein-coupled receptor signaling in a reversible and highly receptor-specific manner.BMC Cell Biol 2005 Jan 01;6(1):21
- 14573771Bodor ET, Waldo GL, Hooks SB, Corbitt J, Boyer JL, Harden TK. Purification and functional reconstitution of the human P2Y12 receptor.Mol Pharmacol 2003 Nov 01;64(5):1210-6 View 230 categorized literature findings and their references in IPA
Molecular Functions
adenosine receptor activity, G-protein coupled, G-protein coupled receptor activity, platelet ADP receptor activity, purinergic nucleotide receptor activity, G-protein coupled, receptor activity, signal transducer activity
Protein Domains
G-protein coupled adenosine receptor, G-protein coupled receptor, platelet ADP receptor
