LAMP1 - lysosomal-associated membrane protein 1
Entrez Gene Name: lysosomal-associated membrane protein 1
Entrez GeneID: Human(3916)
, Mouse(16783), Rat(25328)
, Mouse(16783), Rat(25328) Synonyms: AI196048, CD107A, LAMP1, LAMPA, Lgp110, LGP120
Gene Summary
- Human (3916): The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. [provided by RefSeq]
- Rat (25328): a lysosomal acidic membrane protein [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Cellular Components
endosome, endosome membrane, external side of plasma membrane, integral to membrane, integral to plasma membrane, late endosome, lysosomal membrane, lysosome, melanosome, membrane, membrane fraction, multivesicular body, plasma membrane, sarcolemma
Literature References
- 18701486Fehrenbacher N, Bastholm L, Kirkegaard-Sørensen T, Rafn B, Bøttzauw T, Nielsen C, Weber E, Shirasawa S, Kallunki T, Jäättelä M. Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.Cancer Res 2008 Aug 15;68(16):6623-33
- 18039658Poirier S, Mayer G, Benjannet S, Bergeron E, Marcinkiewicz J, Nassoury N, Mayer H, Nimpf J, Prat A, Seidah NG. The Proprotein Convertase PCSK9 Induces the Degradation of Low Density Lipoprotein Receptor (LDLR) and Its Closest Family Members VLDLR and ApoER2.J Biol Chem 2008 Jan 25;283(4):2363-72
- 10212251Andrejewski N, Punnonen EL, Guhde G, Tanaka Y, Lüllmann-Rauch R, Hartmann D, von Figura K, Saftig P. Normal lysosomal morphology and function in LAMP-1-deficient mice.J Biol Chem 1999 Apr 30;274(18):12692-701 View 446 categorized literature findings and their references in IPA
Subcellular Locations
alveolar epithelial lamellar bodies, cell surface, cellular membrane, cytoplasm, cytoplasmic face of plasma membrane, cytoplasmic vesicles, endocytotic vesicle, endolysosomal tubule, endosomal compartment, endosomal fractions, endosome-lysosome compartments, endosomes, exosomes, late endosomal fractions, late endosomes, lysosome, lysosome fractions, lysosome membrane, melanosomes, membrane compartment, membrane fraction, membrane rafts, membrane surface, multivesicular bodies, outer membranes, perinuclear Golgi regions, perinuclear region, perinuclear vesicles, peripheral vesicles, pH resistant lipid raft fraction, phagocytic cups, phagosomes, plasma membrane, plasma membrane projections, secretory vesicles, synaptic vesicles, vacuole, vesicle membrane, vesicles
