P2RX5 - purinergic receptor P2X, ligand-gated ion channel, 5
Entrez Gene Name: purinergic receptor P2X, ligand-gated ion channel, 5
Entrez GeneID: Human(5026)
, Mouse(94045), Rat(113995)
, Mouse(94045), Rat(113995) Synonyms: MGC47755, P2RX5, P2X5, P2x5 receptor, P2X5R
Gene Summary
- Human (5026): The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Three transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
- Rat (113995): an ATP-gated ion channel [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cation transport, cell surface receptor linked signal transduction, ion transport, nervous system development, positive regulation of calcium ion transport into cytosol, positive regulation of calcium-mediated signaling, protein homooligomerization, regulation of action potential in neuron, regulation of skeletal muscle regeneration, signal transduction, skeletal muscle tissue growth, transport
Literature References
- 17117171Maragakis NJ, Rothstein JD. Mechanisms of Disease: astrocytes in neurodegenerative disease.Nat Clin Pract Neurol 2006 Dec 01;2(12):679-89
- 10510328Taylor AL, Schwiebert LM, Smith JJ, King C, Jones JR, Sorscher EJ, Schwiebert EM. Epithelial P2X purinergic receptor channel expression and function.J Clin Invest 1999 Oct;104(7):875-84
- 12135987Ryten M, Dunn PM, Neary JT, Burnstock G. ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells.J Cell Biol 2002 Jul 22;158(2):345-55 View 76 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, ATP-gated cation channel activity, drug binding, GTP binding, ion channel activity, protein heterodimerization activity, protein homodimerization activity, purinergic nucleotide receptor activity, receptor activity, transmembrane receptor activity, zinc ion binding
Protein Domains
ATP binding, ATP-gated cation channel, drug binding, GTP binding, ion channel, transmembrane receptor, zinc ion binding
