TAC1 - tachykinin, precursor 1
Entrez Gene Name: tachykinin, precursor 1
Entrez GeneID: Human(6863)
, Mouse(21333), Rat(24806)
, Mouse(21333), Rat(24806) Synonyms: 4930528L02Rik, B-ppt, Hs.2563, MGC151458, NEUROKININ A, NEUROPEPTIDE GAMMA, NEUROPEPTIDE K, NK-1, NK2, NKA, NKNA, NPK, PPT-A, PPT-I, Ppt5fl, PPTA3, RATPPTA3, SP, SUBSTANCE P, TAC, TAC1, TAC1 isoform 1, TAC2, Tachykinin
Gene Summary
- Human (6863): This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Rat (24806): encodes neuropeptides substance P, neurokinin A, neuropeptide K, and neuropeptide gamma [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
associative learning, detection of abiotic stimulus, elevation of cytosolic calcium ion concentration, inflammatory response, insemination, long-term memory, negative regulation of heart rate, neuropeptide signaling pathway, positive regulation of action potential, positive regulation of acute inflammatory response, positive regulation of epithelial cell migration, positive regulation of lymphocyte proliferation, positive regulation of natriuresis, positive regulation of ossification, positive regulation of stress fiber formation, positive regulation of synaptic transmission, cholinergic, positive regulation of synaptic transmission, GABAergic, regulation of blood pressure, response to hormone stimulus, response to lipopolysaccharide, response to morphine, response to pain, sensory perception of pain, synaptic transmission, tachykinin receptor signaling pathway
Literature References
- 16122428Guan JS, Xu ZZ, Gao H, He SQ, Ma GQ, Sun T, Wang LH, Zhang ZN, Lena I, Kitchen I, Elde R, Zimmer A, He C, Pei G, Bao L, Zhang X. Interaction with Vesicle Luminal Protachykinin Regulates Surface Expression of delta-Opioid Receptors and Opioid Analgesia.Cell 2005 Aug 26;122(4):619-31
- 17314299Hughes DI, Scott DT, Riddell JS, Todd AJ. Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models.J Neurosci 2007 Feb 21;27(8):2035-44
- 16585602Koon HW, Zhao D, Zhan Y, Rhee SH, Moyer MP, Pothoulakis C. Substance P Stimulates Cyclooxygenase-2 and Prostaglandin E2 Expression through JAK-STAT Activation in Human Colonic Epithelial Cells.J Immunol 2006 Apr 15;176(8):5050-9 View 1433 categorized literature findings and their references in IPA
Subcellular Locations
axon terminals, axons, C fiber, cell surface, dendrites, dense-core vesicles, extracellular space, granules, membrane fraction, nerve ending, nucleus, plasma membrane, synaptic vesicles
