TRAF3IP2 - TRAF3 interacting protein 2
Entrez Gene Name: TRAF3 interacting protein 2
Entrez GeneID: Human(10758)
, Mouse(103213), Rat(361857)
, Mouse(103213), Rat(361857) Synonyms: ACT1, AI429613, C6orf2, C6ORF4, C6orf5, C6orf6, CHROMOSOME 6 OPEN READING FRAME 4, CIKS, DKFZp586G0522, MGC112844, MGC3581, RGD1304768, TRAF3IP2
Gene Summary
- Human (10758): This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Two alternative transcripts encoding different proteins have been identified. A third transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
B cell apoptosis, humoral immune response, immunoglobulin secretion, intracellular signaling cascade, positive regulation of I-kappaB kinase/NF-kappaB cascade
Literature References
- 16189514Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M. Towards a proteome-scale map of the human protein-protein interaction network.Nature 2005 Oct 20;437(7062):1173-8
- 10962033Leonardi A, Chariot A, Claudio E, Cunningham K, Siebenlist U. CIKS, a connection to Ikappa B kinase and stress-activated protein kinase.Proc Natl Acad Sci U S A 2000 Sep 12;97(19):10494-9
- 10962024Li X, Commane M, Nie H, Hua X, Chatterjee-Kishore M, Wald D, Haag M, Stark GR. Act1, an NF-kappa B-activating protein.Proc Natl Acad Sci U S A 2000 Sep 12;97(19):10489-93 View 92 categorized literature findings and their references in IPA
