GRIN2A - glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Entrez Gene Name: glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Entrez GeneID: Human(2903)
, Mouse(14811), Rat(24409)
, Mouse(14811), Rat(24409) Synonyms: GLUR EPSILON 1, GRIN2A, Nmda receptor epsilon1, NMDAR2A, NR2A
Gene Summary
- Human (2903): N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- Rat (24409): may play a role in synaptic transmission, learning and memory [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
calcium ion transport, detection of mechanical stimulus involved in sensory perception of pain, directional locomotion, dopamine metabolic process, glutamate signaling pathway, ion transport, ionotropic glutamate receptor signaling pathway, learning, learning or memory, locomotion, locomotory behavior, memory, negative regulation of protein catabolic process, neurogenesis, positive regulation of apoptosis, protein localization, regulation of action potential, regulation of excitatory postsynaptic membrane potential, regulation of long-term neuronal synaptic plasticity, regulation of membrane potential, regulation of postsynaptic membrane potential, regulation of sensory perception of pain, regulation of synaptic plasticity, response to amphetamine, response to drug, response to ethanol, response to wounding, rhythmic process, sensory perception of pain, serotonin metabolic process, sleep, startle response, synaptic transmission, transport, visual learning
Cellular Components
cell junction, cytoplasm, dendritic spine, integral to membrane, integral to plasma membrane, membrane, membrane fraction, N-methyl-D-aspartate selective glutamate receptor complex, neuron projection, plasma membrane, postsynaptic density, postsynaptic membrane, presynaptic membrane, synapse, synaptosome
Literature References
- 10774735Fayyazuddin A, Villarroel A, Le Goff A, Lerma J, Neyton J. Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors.Neuron 2000 Mar 1;25(3):683-94
- 17329232Carter CJ. EIF2B and Oligodendrocyte Survival: Where Nature and Nurture Meet in Bipolar Disorder and Schizophrenia?Schizophr Bull 2007 Nov 01;33(6):1343-53
- 17188796Fan MM, Raymond LA. N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease.Prog Neurobiol 2007 Apr 01;81(5-6):272-93 View 1331 categorized literature findings and their references in IPA
Molecular Functions
calcium channel activity, calcium ion binding, cation channel activity, cell adhesion molecule binding, extracellular-glutamate-gated ion channel activity, glutamate binding, ion channel activity, ionotropic glutamate receptor activity, magnesium ion binding, N-methyl-D-aspartate selective glutamate receptor activity, neurotransmitter binding, protein binding, receptor activity, voltage-gated cation channel activity
Protein Domains
calcium channel, carboxy terminal domain, cation channel, cytoplasmic domain, extracellular ligand binding domain, glutamate binding, glutamate-gated ion channel, ion channel, ionotropic glutamate receptor, N-methyl-D-aspartate selective glutamate receptor, neurotransmitter binding, protein binding
Subcellular Locations
cell body, cell surface, cellular membrane, dendrites, dendritic shafts, dendritic spines, detergent-insoluble fractions, endoplasmic reticulum, membrane fraction, plasma membrane, postsynaptic density, postsynaptic density (PSD) fractions, soluble fraction, synapse, synaptic membrane, synaptic vesicle fractions, synaptosomal fractions, synaptosomes, vesicle fraction
