CHAT - choline acetyltransferase
Entrez Gene Name: choline acetyltransferase
Entrez GeneID: Human(1103)
, Mouse(12647), Rat(290567)
, Mouse(12647), Rat(290567) Synonyms: B230380D24Rik, CHAT, CHOACTase, CHOLINE ACETYLTRANSFERASE, CMS1A, CMS1A2
Gene Summary
- Human (1103): This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer disease. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
acetylcholine biosynthetic process, adult walking behavior, antral ovarian follicle growth, dendrite development, establishment of synaptic specificity at neuromuscular junction, memory, muscle organ development, neuromuscular synaptic transmission, neuron differentiation, neurotransmitter biosynthetic process, response to drug, response to ethanol, response to hypoxia, response to nutrient, rhythmic behavior, rhythmic excitation, synaptic transmission
Literature References
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 17522308von Engelhardt J, Eliava M, Meyer AH, Rozov A, Monyer H. Functional characterization of intrinsic cholinergic interneurons in the cortex.J Neurosci 2007 May 23;27(21):5633-42
- 9639663Connor B, Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain.Brain Res Brain Res Rev 1998 Jun 01;27(1):1-39 View 509 categorized literature findings and their references in IPA
Molecular Functions
acyltransferase activity, choline binding, choline O-acetyltransferase activity, transferase activity
Subcellular Locations
axons, cell body, cytoplasm, membrane processes, nucleus, perikaryon, perinuclear region
