CRMP1 - collapsin response mediator protein 1
Entrez Gene Name: collapsin response mediator protein 1
Entrez GeneID: Human(1400)
, Mouse(12933), Rat(25415)
, Mouse(12933), Rat(25415) Synonyms: CRMP1, DPYSL1, DRP-1, Tuc-1a, Ulip3
Gene Summary
- Human (1400): This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq]
- Rat (25415): protein that may play a role in neuronal plasticity by transduction of signals from semaphorins [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
nervous system development, neuron development, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
Literature References
- 16169070Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE. A human protein-protein interaction network: a resource for annotating the proteome.Cell 2005 Sep 23;122(6):957-68
- 18003833Yamashita N, Morita A, Uchida Y, Nakamura F, Usui H, Ohshima T, Taniguchi M, Honnorat J, Thomasset N, Takei K, Takahashi T, Kolattukudy P, Goshima Y. Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1.J Neurosci 2007 Nov 14;27(46):12546-54
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363 View 249 categorized literature findings and their references in IPA
Molecular Functions
dihydropyrimidinase activity, hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, protein binding
Subcellular Locations
cell body, centrosome, cytoplasm, dendrites, midbody, mitotic spindle, neuritic shafts, nucleus, postsynaptic density (PSD) fractions, synaptosomal fractions
