SNCG - synuclein, gamma (breast cancer-specific protein 1)
Entrez Gene Name: synuclein, gamma (breast cancer-specific protein 1)
Entrez GeneID: Human(6623)
, Mouse(20618), Rat(64347)
, Mouse(20618), Rat(64347) Synonyms: BCSG1, breast cancer-specific protein 1, C79089, Persyn, SNCG, SR, SYNORETIN, SYNUCLEIN GAMMA
Gene Summary
- Human (6623): Summary: This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development. [provided by RefSeq]
- Rat (64347): may play a role in the neurofilament network [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
adult locomotory behavior, peripheral nervous system development, regulation of dopamine secretion, regulation of neurotransmitter secretion
Cellular Components
axon, cell soma, centrosome, cytoplasm, nerve terminal, perinuclear region of cytoplasm, spindle
Literature References
- 17353931Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. Large-scale mapping of human protein-protein interactions by mass spectrometry.Mol Syst Biol 2007 01 1;3:89
- 14585981Ninkina N, Papachroni K, Robertson DC, Schmidt O, Delaney L, O'Neill F, Court F, Rosenthal A, Fleetwood-Walker SM, Davies AM, Buchman VL. Neurons expressing the highest levels of gamma-synuclein are unaffected by targeted inactivation of the gene.Mol Cell Biol 2003 Nov 01;23(22):8233-45
- 14576821Gupta A, Inaba S, Wong OK, Fang G, Liu J. Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1.Oncogene 2003 Oct 23;22(48):7593-9 View 303 categorized literature findings and their references in IPA
Subcellular Locations
axons, cell body, cytoplasm, cytosol, cytosolic fraction, growth cone, presynaptic terminals
