HTR4 - 5-hydroxytryptamine (serotonin) receptor 4
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 4
Entrez GeneID: Human(3360)
, Mouse(15562), Rat(25324)
, Mouse(15562), Rat(25324) Synonyms: 5-HT, 5-HT4, 5-HT4R, 5HT4SR, HTR4, Serotonin receptor 4
Gene Summary
- Human (3360): This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined. [provided by RefSeq]
- Rat (25324): receptor for serotonin; may play a role in cognition and anxiolysis [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of adenylate cyclase activity by G-protein signaling pathway, cognition, G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, gamma-aminobutyric acid signaling pathway, signal transduction
Cellular Components
endosome, integral to membrane, integral to plasma membrane, membrane, membrane fraction, plasma membrane
Literature References
- 7796807Gerald C, Adham N, Kao HT, Olsen MA, Laz TM, Schechter LE, Bard JA, Vaysse PJ, Hartig PR, Branchek TA. The 5-HT4 receptor: molecular cloning and pharmacological characterization of two splice variants.EMBO J 1995 06 15;14(12):2806-15
- 17913892Jean A, Conductier G, Manrique C, Bouras C, Berta P, Hen R, Charnay Y, Bockaert J, Compan V. Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens.Proc Natl Acad Sci U S A 2007 Oct 09;104(41):16335-40
- 17377064Barthet G, Framery B, Gaven F, Pellissier L, Reiter E, Claeysen S, Bockaert J, Dumuis A. 5-hydroxytryptamine 4 receptor activation of the extracellular signal-regulated kinase pathway depends on Src activation but not on G protein or beta-arrestin signaling.Mol Biol Cell 2007 Jun 01;18(6):1979-91 View 566 categorized literature findings and their references in IPA
Molecular Functions
G-protein coupled receptor activity, receptor activity, serotonin receptor activity, signal transducer activity
Subcellular Locations
cell surface, cellular membrane, dense granules, membrane fraction, plasma membrane
