E2F4 - E2F transcription factor 4, p107/p130-binding
Entrez Gene Name: E2F transcription factor 4, p107/p130-binding
Entrez GeneID: Human(1874)
, Mouse(104394), Rat(307794)
, Mouse(104394), Rat(307794) Synonyms: 2010111M04Rik, AI427446, E2F4
Gene Summary
- Human (1874): The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
blood circulation, cell cycle, cell volume homeostasis, cilium assembly, epithelial cell development, organ morphogenesis, regulation of cell cycle, regulation of cell proliferation, regulation of cell size, regulation of transcription of G1/S-phase of mitotic cell cycle, regulation of transcription, DNA-dependent, transcription
Literature References
- 12757710Iakova P, Awad SS, Timchenko NA. Aging Reduces Proliferative Capacities of Liver by Switching Pathways of C/EBPalpha Growth Arrest.Cell 2003 May 16;113(4):495-506
- 12150994Chen CR, Kang Y, Siegel PM, Massagué J. E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression.Cell 2002 Jul 12;110(1):19-32
- 11799067Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints.Genes Dev 2002 Jan 15;16(2):245-56 View 1867 categorized literature findings and their references in IPA
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Role of BRCA1 in DNA Damage Response
- Pancreatic Adenocarcinoma Signaling
- Colorectal Cancer Metastasis Signaling
- Glioma Signaling
- Cell Cycle Regulation by BTG Family Proteins
- Molecular Mechanisms of Cancer
- Chronic Myeloid Leukemia Signaling
- Cell Cycle: G1/S Checkpoint Regulation
Protein Domains
DNA binding, DNA binding domain, protein binding, transcription factor, transcription regulator
Subcellular Locations
chromatin, cytoplasm, cytoplasmic fraction, cytosol, nuclear fraction, nucleus
