CTBP1 - C-terminal binding protein 1
Entrez Gene Name: C-terminal binding protein 1
Entrez GeneID: Human(1487)
, Mouse(13016), Rat(29382)
, Mouse(13016), Rat(29382) Synonyms: 50-kDaBFA-inducedADP-ribosylatedsubstrate, BARS, BARS-50, CTBP, CTBP1, CtBP1-L, CtBP1-S, CtBP3/BARS, D4S115h, D5H4S115, D5H4S115E, MGC104684, MGC93318
Gene Summary
- Human (1487): This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
Golgi organization, membrane fusion, metabolic process, negative regulation of cell proliferation, negative regulation of transcription from RNA polymerase II promoter, oxidation reduction, protein amino acid phosphorylation, viral genome replication
Literature References
- 14567915Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.Cell 2003 Oct 17;115(2):177-86
- 12700765Shi Y, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Po-Shan Luke M, Nakatani Y, Shi Y. Coordinated histone modifications mediated by a CtBP co-repressor complex.Nature 2003 Apr 17;422(6933):735-8
- 12679040Kagey MH, Melhuish TA, Wotton D. The Polycomb Protein Pc2 Is a SUMO E3.Cell 2003 Apr 4;113(1):127-37 View 585 categorized literature findings and their references in IPA
Molecular Functions
acyltransferase activity, binding, catalytic activity, cofactor binding, NAD or NADH binding, oxidoreductase activity, oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, protein binding, protein C-terminus binding, transcription corepressor activity, transcription factor activity, transcription factor binding
Protein Domains
enzyme, NAD binding domain, protein binding, protein C-terminus binding, transcription co-repressor, transcription factor, transcription factor binding, transferase, transferring acyl groups
Subcellular Locations
cytoplasm, cytosol, nuclear bodies, nucleus, polycomb group domain, ribbon synapse, synapse, synaptosomal fractions
