FGFR2 - fibroblast growth factor receptor 2
Entrez Gene Name: fibroblast growth factor receptor 2
Entrez GeneID: Human(2263)
, Mouse(14183), Rat(25022)
, Mouse(14183), Rat(25022) Synonyms: AU043015, AW556123, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, Fgfr-7, FGFR2, Fgfr2 3c, Fgfr2b, Fgfr2b isoform, Fgfr2c isoform, FLJ98662, JWS, K-SAM, KGFR, KGFRTr, MGC102519, svs, TK14, TK25
Gene Summary
- Human (2263): The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]
- Rat (25022): may play a role in mesodermal cell differentiation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiogenesis, bone mineralization, branching involved in salivary gland morphogenesis, cell fate commitment, cell growth, cell-cell signaling, embryonic organ development, embryonic organ morphogenesis, embryonic placenta development, epithelial cell proliferation, epithelial to mesenchymal transition, fibroblast growth factor receptor signaling pathway, in utero embryonic development, inner ear morphogenesis, lacrimal gland development, limb bud formation, lung development, mesenchymal cell differentiation, mesodermal cell differentiation, midbrain development, morphogenesis of embryonic epithelium, negative regulation of epithelial cell proliferation, otic vesicle formation, positive regulation of cardiac muscle cell proliferation, positive regulation of cell proliferation, positive regulation of mesenchymal cell proliferation, positive regulation of smooth muscle cell proliferation, protein amino acid phosphorylation, regulation of cell proliferation, regulation of multicellular organism growth, salivary gland morphogenesis, ureteric bud development
Cellular Components
cell surface, cytoplasm, extracellular region, integral to membrane, membrane, nucleus, plasma membrane
Literature References
- 17529967Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG, Struewing JP, Morrison J, Field H, Luben R, Wareham N, Ahmed S, Healey CS, Bowman R, SEARCH collaborators, Meyer KB, Haiman CA, Kolonel LK, Henderson BE, Le Marchand L, Brennan P, Sangrajrang S, Gaborieau V, Odefrey F, Shen CY, Wu PE, Wang HC, Eccles D, Evans DG, Peto J, Fletcher O, Johnson N, Seal S, Stratton MR, Rahman N, Chenevix-Trench G, Bojesen SE, Nordestgaard BG, Axelsson CK, Garcia-Closas M, Brinton L, Chanock S, Lissowska J, Peplonska B, Nevanlinna H, Fagerholm R, Eerola H, Kang D, Yoo KY, Noh DY, Ahn SH, Hunter DJ, Hankinson SE, Cox DG, Hall P, Wedren S, Liu J, Low YL, Bogdanova N, Schürmann P, Dörk T, Tollenaar RA, Jacobi CE, Devilee P, Klijn JG, Sigurdson AJ, Doody MM, Alexander BH, Zhang J, Cox A, Brock IW, MacPherson G, Reed MW, Couch FJ, Goode EL, Olson JE, Meijers-Heijboer H, van den Ouweland A, Uitterlinden A, Rivadeneira F, Milne RL, Ribas G, Gonzalez-Neira A, Benitez J, Hopper JL, McCredie M, Southey M, Giles GG, Schroen C, Justenhoven C, Brauch H, Hamann U, Ko YD, Spurdle AB, Beesley J, Chen X, kConFab, AOCS Management Group, Mannermaa A, Kosma VM, Kataja V, Hartikainen J, Day NE, Cox DR, Ponder BA. Genome-wide association study identifies novel breast cancer susceptibility loci.Nature 2007 06 28;447(7148):1087-93
- 15502875John B, Enright AJ, Aravin A, Tuschl T, Sander C, Marks DS. Human MicroRNA targets.PLoS Biol 2004 11 1;2(11):e363
- 15260994Umemori H, Linhoff MW, Ornitz DM, Sanes JR. FGF22 and Its Close Relatives Are Presynaptic Organizing Molecules in the Mammalian Brain.Cell 2004 Jul 23;118(2):257-70 View 1876 categorized literature findings and their references in IPA
Molecular Functions
ATP binding, fibroblast growth factor 1 binding, fibroblast growth factor binding, fibroblast growth factor receptor activity, heparin binding, kinase activity, nucleotide binding, protein binding, protein kinase activity, protein tyrosine kinase activity, receptor activity, transferase activity, transmembrane receptor protein tyrosine kinase activity
Protein Domains
acidic domain, extracellular domain, fibroblast growth factor binding, fibroblast growth factor receptor, immunoglobulin domain, immunoglobulin-like protein domain, kinase, protein binding, protein-tyrosine kinase, transmembrane domain
Subcellular Locations
cell surface, cellular membrane, cytoplasm, endoplasmic reticulum, extracellular space, nuclear scaffolds, plasma membrane, trans Golgi network, vesicles
