PTPRC - protein tyrosine phosphatase, receptor type, C
Entrez Gene Name: protein tyrosine phosphatase, receptor type, C
Entrez GeneID: Human(5788)
, Mouse(19264), Rat(24699)
, Mouse(19264), Rat(24699) Synonyms: B220, CD45, CD45R, GP180, L-CA, loc, Ly-5, Lyt-4, Ox1, PTPRC, RT7, T200
Gene Summary
- Human (5788): The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]
- Rat (24699): member of a family of heavily glycosylated leukocyte cell surface glycoproteins; displays extensive O-glycosylation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, B cell differentiation, B cell receptor signaling pathway, cell surface receptor linked signal transduction, defense response to virus, dephosphorylation, heterotypic cell-cell adhesion, immunoglobulin biosynthetic process, leukocyte adhesion, negative regulation of cytokine-mediated signaling pathway, negative regulation of peptidyl-tyrosine phosphorylation, negative regulation of protein amino acid autophosphorylation, negative regulation of protein kinase activity, negative regulation of T cell mediated cytotoxicity, negative thymic T cell selection, positive regulation of alpha-beta T cell proliferation, positive regulation of antigen receptor-mediated signaling pathway, positive regulation of apoptosis, positive regulation of B cell proliferation, positive regulation of gamma-delta T cell differentiation, positive regulation of humoral immune response mediated by circulating immunoglobulin, positive regulation of isotype switching to IgG isotypes, positive regulation of MAPKKK cascade, positive regulation of protein kinase activity, positive regulation of T cell differentiation, positive regulation of T cell mediated cytotoxicity, positive regulation of T cell mediated immunity, positive regulation of T cell proliferation, positive thymic T cell selection, protein amino acid dephosphorylation, regulation of apoptosis, regulation of B cell differentiation, regulation of B cell receptor signaling pathway, regulation of cell cycle, regulation of humoral immune response mediated by circulating immunoglobulin, regulation of S phase, release of sequestered calcium ion into cytosol, response to gamma radiation, T cell differentiation, T cell proliferation, T cell receptor signaling pathway
Cellular Components
cell surface, external side of plasma membrane, focal adhesion, integral to membrane, integral to plasma membrane, internal side of plasma membrane, membrane, nucleus, plasma membrane
Literature References
- 12354383Pradhan D, Morrow J. The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production.Immunity 2002 Sep;17(3):303-15
- 11201744Irie-Sasaki J, Sasaki T, Matsumoto W, Opavsky A, Cheng M, Welstead G, Griffiths E, Krawczyk C, Richardson CD, Aitken K, Iscove N, Koretzky G, Johnson P, Liu P, Rothstein DM, Penninger JM. CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling.Nature 2001 Jan 18;409(6818):349-54
- 15867094Huntington ND, Xu Y, Nutt SL, Tarlinton DM. A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.J Exp Med 2005 May 02;201(9):1421-33 View 1583 categorized literature findings and their references in IPA
Molecular Functions
heparan sulfate proteoglycan binding, heparin binding, hydrolase activity, phosphatase activity, phosphoprotein phosphatase activity, protein binding, protein kinase binding, protein kinase regulator activity, protein tyrosine phosphatase activity, transmembrane receptor protein tyrosine phosphatase activity
Protein Domains
cytoplasmic domain, ectodomain, extracellular domain, Fibronectin type III domain, heparin binding, phosphatase, phosphatase domain, protein binding, protein kinase binding, protein kinase regulator, protein-tyrosine-phoshatase, PTPase domain, transmembrane domain, transmembrane receptor protein tyrosine phosphatase
Subcellular Locations
cell periphery, cell surface, cellular membrane, detergent-soluble fraction, exosomes, intracellular space, membrane blebs, membrane fraction, membrane rafts, pH resistant lipid raft fraction, plasma membrane
