ABI1 - abl-interactor 1
Entrez Gene Name: abl-interactor 1
Entrez GeneID: Human(10006)
, Mouse(11308), Rat(79249)
, Mouse(11308), Rat(79249) Synonyms: Abelson interactor 1, ABI1, Abl binding protein 4, E3B1, Eps8 binding, MGC6064, NAP1, Nap1 binding, NAP1BP, SSH3BP, SSH3BP1
Gene Summary
- Human (10006): The protein encoded by this gene has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Disease:
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Biological Process
cellular process, negative regulation of cell proliferation, peptidyl-tyrosine phosphorylation, somitogenesis, transmembrane receptor protein tyrosine kinase signaling pathway
Cellular Components
cell junction, cell leading edge, cell projection, cytoplasm, cytoskeleton, cytosol, endoplasmic reticulum, filopodium, growth cone, intracellular, lamellipodium, nucleus, soluble fraction, synapse, synaptosome
Literature References
- 18044991Yang C, Czech L, Gerboth S, Kojima S, Scita G, Svitkina T. Novel Roles of Formin mDia2 in Lamellipodia and Filopodia Formation in Motile Cells.PLoS Biol 2007 Nov 27;5(11):e317
- 10499589Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP. EPS8 and E3B1 transduce signals from Ras to Rac.Nature 1999 Sep 16;401(6750):290-3
- 9585502Dai Z, Quackenbush RC, Courtney KD, Grove M, Cortez D, Reuther GW, Pendergast AM. Oncogenic Abl and Src tyrosine kinases elicit the ubiquitin-dependent degradation of target proteins through a Ras-independent pathway.Genes Dev 1998 May 15;12(10):1415-24 View 452 categorized literature findings and their references in IPA
Molecular Functions
cytoskeletal protein binding, protein binding, protein tyrosine kinase activator activity
Protein Domains
cytoskeletal protein binding, homeodomain, protein binding, protein tyrosine kinase activator, SH3 domain, Sh3 domain binding motif, SH3-domain binding, SNARE motif, spectrin binding
Subcellular Locations
actin filaments, cell membrane leading edge, cell surface, cellular membrane, cytoplasm, cytoskeleton, cytosol, nucleus, vesicles
