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HTR1D - 5-hydroxytryptamine (serotonin) receptor 1D
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 1D
Synonyms: 5-HT1D, 5HT1D RECEPTOR, AI853647, Gpcr14, HT1DA, HTR1D, HTR1DA, HTRL, RDC4

Gene Summary

  • Rat (25323): G-protein coupled receptor for serotonin; found in nociceptors throughout the body [RGD]

Cell Regulation

Regulates:
  • Plc
View all 2 in IPA
Regulated by:
  • clozapine
  • risperidone
  • tamsulosin
View all 30 in IPA
Binds:
  • ergotamine
  • zolmitriptan
  • 5-hydroxytryptamine
View all 28 in IPA
Role in cell:
  • aggregation
View all 2 in IPA
Disease:
  • migraines
  • anxiety
  • cocaine-related disorder
View all 11 in IPA

Biological Process

G-protein coupled receptor protein signaling pathway, G-protein signaling, coupled to cyclic nucleotide second messenger, response to toxin, signal transduction, synaptic transmission

Cellular Components

integral to membrane, integral to plasma membrane, membrane, plasma membrane

Literature References

  • 12388666Millan MJ, Maiofiss L, Cussac D, Audinot V, Boutin JA, Newman-Tancredi A. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes.J Pharmacol Exp Ther 2002 Nov 01;303(2):791-804
  • 12388668Newman-Tancredi A, Cussac D, Quentric Y, Touzard M, Verriele L, Carpentier N, Millan MJ. Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. III. Agonist and antagonist properties at serotonin, 5-HT(1) and 5-HT(2), receptor subtypes.J Pharmacol Exp Ther 2002 Nov;303(2):815-22
  • 11114882Bibel M, Barde YA. Neurotrophins: key regulators of cell fate and cell shape in the vertebrate nervous system.Genes Dev 2000 Dec 01;14(23):2919-37
  • View 149 categorized literature findings and their references in IPA

Molecular Functions

G-protein coupled receptor activity, receptor activity, serotonin binding, serotonin receptor activity, signal transducer activity

Protein Domains

G-protein coupled receptor, serotonin receptor

Subcellular Locations

cellular membrane, plasma membrane

IPA Extras

View additional information available in IPA's curated and annotated database: