FGF2 - fibroblast growth factor 2 (basic)
Entrez Gene Name: fibroblast growth factor 2 (basic)
Entrez GeneID: Human(2247)
, Mouse(14173), Rat(54250)
, Mouse(14173), Rat(54250) Synonyms: BASIC FIBROBLAST GROWTH FACTOR, BFGF, bFGF-2, FGF2, FGF2 22, FGFB, HBGF-2
Gene Summary
- Human (2247): The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq]
- Rat (54250): activates the MAP kinase signaling pathway; plays a role in synaptic transmission; induces cell proliferation [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, activation of MAPKK activity, angiogenesis, apoptosis, C21-steroid hormone biosynthetic process, cell differentiation, cell proliferation, chemotaxis, fibroblast growth factor receptor signaling pathway, glial cell differentiation, induction of an organ, lung development, multicellular organismal development, negative regulation of blood vessel endothelial cell migration, negative regulation of cell growth, negative regulation of cell proliferation, negative regulation of transcription, DNA-dependent, nervous system development, nuclear translocation of MAPK, organ morphogenesis, positive regulation of angiogenesis, positive regulation of blood vessel endothelial cell migration, positive regulation of cardiac muscle cell proliferation, positive regulation of cell differentiation, positive regulation of cell proliferation, positive regulation of epithelial cell proliferation, positive regulation of granule cell precursor proliferation, positive regulation of protein amino acid phosphorylation, positive regulation of transcription, positive regulation of transcription from RNA polymerase II promoter, protein kinase cascade, Ras protein signal transduction, regulation of calcium ion-dependent exocytosis, regulation of retinal cell programmed cell death, regulation of transcription, DNA-dependent, signal transduction, synaptic transmission, wound healing
Literature References
- 16107612Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis.Genes Dev 2005 Sep 01;19(17):2054-65
- 9858769Herdegen T, Leah JD. Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins.Brain Res Brain Res Rev 1998 Dec;28(3):370-490
- 9131253Hefti F. Pharmacology of neurotrophic factors.Annu Rev Pharmacol Toxicol 1997 Jan 01;37:239-67 View 5180 categorized literature findings and their references in IPA
Molecular Functions
growth factor activity, heparin binding, nerve growth factor receptor binding, protein binding, voltage-gated calcium channel activity
Subcellular Locations
basement membrane, cajal bodies, cell periphery, cell surface, chromatin, chromosomes, cytoplasm, cytoplasmic fraction, cytosol, detergent resistant lipid raft fraction, early endosomes, extracellular space, gems, Herring bodies, intracellular space, membrane surface, mitochondria, nuclear bodies, nuclear fraction, nucleolar periphery, nucleoli, nucleoplasm, nucleus, plasma membrane
