HTR3B - 5-hydroxytryptamine (serotonin) receptor 3B
Entrez Gene Name: 5-hydroxytryptamine (serotonin) receptor 3B
Entrez GeneID: Human(9177)
, Mouse(57014), Rat(58963)
, Mouse(57014), Rat(58963) Synonyms: 5-HT3B, HTR3B
Gene Summary
- Human (9177): The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. [provided by RefSeq]
- Rat (58963): a serotonin-gated ion channel subunit with pronounced inward rectification of both the whole-cell and single-channel current amplitudes [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
ion transport, serotonin receptor signaling pathway, synaptic transmission, transport
Cellular Components
integral to membrane, integral to plasma membrane, membrane, plasma membrane, postsynaptic membrane
Literature References
- 9950429Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF. The 5-HT3B subunit is a major determinant of serotonin-receptor function.Nature 1999 Jan 28;397(6717):359-63
- 10026168Yan D, Schulte MK, Bloom KE, White MM. Structural features of the ligand-binding domain of the serotonin 5HT3 receptor.J Biol Chem 1999 Feb 26;274(9):5537-41
- 9698312Bedford FK, Julius D, Ingraham HA. Neuronal expression of the 5HT3 serotonin receptor gene requires nuclear factor 1 complexes.J Neurosci 1998 Aug 15;18(16):6186-94 View 298 categorized literature findings and their references in IPA
Molecular Functions
extracellular ligand-gated ion channel activity, ion channel activity, neurotransmitter receptor activity, receptor activity, serotonin receptor activity, serotonin-activated cation-selective channel activity
Protein Domains
extracellular ligand binding domain, ion channel, neurotransmitter-gated ion channel ligand binding domain, serotonin receptor, serotonin-activated cation-selective channel
