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KBTBD10 - kelch repeat and BTB (POZ) domain containing 10
Entrez Gene Name: kelch repeat and BTB (POZ) domain containing 10
Synonyms: Gm112, KBTBD10, Kel-like protein 23, KRP1, SARCOSIN

Gene Summary

  • Rat (117537): required for pseudopod elongation in fibroblasts [RGD]

Cell Regulation

Regulates:
  • No Data Available
Regulated by:
  • genistein
  • nonylphenol
  • bisphenol A
View all 5 in IPA
Binds:
  • SLC2A4
  • NEB
View all 3 in IPA
Role in cell:
  • length
View all 2 in IPA
Disease:
  • No Data Available

Biological Process

cell motion, modification-dependent protein catabolic process, regulation of lateral pseudopodium assembly, striated muscle contraction

Cellular Components

cytoplasm, cytoskeleton, pseudopodium, ruffle

Literature References

  • 10713668Spence HJ, Johnston I, Ewart K, Buchanan SJ, Fitzgerald U, Ozanne BW. Krp1, a novel kelch related protein that is involved in pseudopod elongation in transformed cells.Oncogene 2000 Mar 2;19(10):1266-76
  • 16449658Spence HJ, McGarry L, Chew CS, Carragher NO, Scott-Carragher LA, Yuan Z, Croft DR, Olson MF, Frame M, Ozanne BW. AP-1 Differentially Expressed Proteins Krp1 and Fibronectin Cooperatively Enhance Rho-ROCK-Independent Mesenchymal Invasion by Altering the Function, Localization, and Activity of Nondifferentially Expressed Proteins.Mol Cell Biol 2006 Feb 01;26(4):1480-95
  • 17010207Hong EJ, Park SH, Choi KC, Leung PC, Jeung EB. Identification of estrogen-regulated genes by microarray analysis of the uterus of immature rats exposed to endocrine disrupting chemicals.Reprod Biol Endocrinol 2006 Jan 01;4:49
  • View 28 categorized literature findings and their references in IPA

Molecular Functions

protein binding

Pathways

No Data Available

Protein Domains

kelch repeat, POZ domain, protein binding

Subcellular Locations

cytoplasm, membrane ruffles, pseudopodia

IPA Extras