CUL1 - cullin 1
Entrez Gene Name: cullin 1
Entrez GeneID: Human(8454)
, Mouse(26965), Rat(362356)
, Mouse(26965), Rat(362356) Synonyms: CUL1, CULLIN HOMOLOG 1, CULLIN1, MGC149834, MGC149835
Gene Summary
No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
apoptosis, cell cycle arrest, cell proliferation, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, modification-dependent protein catabolic process, negative regulation of cell proliferation, organ morphogenesis, positive regulation of ubiquitin-protein ligase activity during mitotic cell cycle, ubiquitin-dependent protein catabolic process
Cellular Components
cullin-RING ubiquitin ligase complex, cytosol, nucleoplasm, SCF ubiquitin ligase complex
Literature References
- 11961546Zheng N, Schulman BA, Song L, Miller JJ, Jeffrey PD, Wang P, Chu C, Koepp DM, Elledge SJ, Pagano M, Conaway RC, Conaway JW, Harper JW, Pavletich NP. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex.Nature 2002 04 18;416(6882):703-9
- 11337588Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome.Science 2001 05 18;292(5520):1382-5
- 11032804Wirbelauer C, Sutterlüty H, Blondel M, Gstaiger M, Peter M, Reymond F, Krek W. The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts.EMBO J 2000 Oct 16;19(20):5362-75 View 778 categorized literature findings and their references in IPA
Molecular Functions
protein binding, ubiquitin protein ligase binding, ubiquitin-protein ligase activity
