FRS2 - fibroblast growth factor receptor substrate 2
Entrez Gene Name: fibroblast growth factor receptor substrate 2
Entrez GeneID: Human(10818)
, Mouse(327826), Rat(314850)
, Mouse(327826), Rat(314850) Synonyms: 4732458E18, C330018A15Rik, FRS2, FRS2 ALPHA, FRS2A, SNT, SNT-1
Gene Summary
No Data Available
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
activation of MAPK activity, determination of anterior/posterior axis, embryo, fibroblast growth factor receptor signaling pathway, forebrain development, G-protein coupled receptor protein signaling pathway, gastrulation with mouth forming second, induction of an organ, intracellular signaling cascade, neuroblast proliferation, optic placode formation involved in camera-type eye, transmembrane receptor protein tyrosine kinase signaling pathway, transmembrane receptor protein tyrosine phosphatase signaling pathway
Cellular Components
cytoplasm, endomembrane system, endosome, integral to plasma membrane, membrane, membrane fraction, plasma membrane
Literature References
- 17623664Kurosu H, Choi M, Ogawa Y, Dickson AS, Goetz R, Eliseenkova AV, Mohammadi M, Rosenblatt KP, Kliewer SA, Kuro-O M. Tissue-specific Expression of betaKlotho and Fibroblast Growth Factor (FGF) Receptor Isoforms Determines Metabolic Activity of FGF19 and FGF21.J Biol Chem 2007 Sep 14;282(37):26687-95
- 17545628Kondo T, Zheng L, Liu W, Kurebayashi J, Asa SL, Ezzat S. Epigenetically controlled fibroblast growth factor receptor 2 signaling imposes on the RAS/BRAF/mitogen-activated protein kinase pathway to modulate thyroid cancer progression.Cancer Res 2007 Jun 01;67(11):5461-70
- 12598680Segal RA. Selectivity in neurotrophin signaling: theme and variations.Annu Rev Neurosci 2003 Jan 01;26:299-330 View 411 categorized literature findings and their references in IPA
Molecular Functions
insulin receptor binding, phosphatase activator activity, protein binding, transmembrane receptor protein tyrosine kinase adaptor protein activity, transmembrane receptor protein tyrosine kinase docking protein activity
Protein Domains
effector domain, phosphatase activator, phosphotyrosine binding domain, protein binding, regulator of G-protein signaling, transmembrane receptor protein tyrosine kinase adaptor protein, transmembrane receptor protein tyrosine kinase docking protein
Subcellular Locations
cellular membrane, cytoplasm, detergent resistant lipid raft fraction, plasma membrane, raft fractions
