ACE - angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Entrez Gene Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Entrez GeneID: Human(1636)
, Mouse(11421), Rat(24310)
, Mouse(11421), Rat(24310) Synonyms: ACE, ACE isoform 3, ACE1, AW208573, CD143, DCP, DCP1, KININASE II, MGC117827, MGC26566, MVCD3, Peptidyldipeptidase I, StsRR92
Gene Summary
- Human (1636): This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined. [provided by RefSeq]
- Rat (24310): catalyzes the conversion of angiotensin I to angiotensin II; plays a role in regulation of blood pressure [RGD]
Molecular Functions | Biological Process | Cellular Components | Protein Domains | Subcellular Locations | Pathways | Literature References | IPA Extras
Cell Regulation
Biological Process
angiotensin catabolic process in blood, arachidonic acid secretion, hemopoietic stem cell differentiation, hormone catabolic process, kidney development, metabolic process, mononuclear cell proliferation, peptide catabolic process, peptide metabolic process, proteolysis, regulation of blood pressure, regulation of smooth muscle cell migration, regulation of systemic arterial blood pressure by renin-angiotensin, regulation of vasoconstriction, regulation of vasodilation, response to hypoxia
Cellular Components
endosome, external side of plasma membrane, extracellular region, extracellular space, integral to membrane, membrane, membrane fraction, plasma membrane
Literature References
- 17303665Chipitsyna G, Gong Q, Gray CF, Haroon Y, Kamer E, Arafat HA. Induction of Monocyte Chemoattractant Protein-1 Expression by Angiotensin II in the Pancreatic Islets and {beta}-Cells.Endocrinology 2007 May 01;148(5):2198-208
- 16476786Kohlstedt K, Gershome C, Friedrich M, Muller-Esterl W, Alhenc-Gelas F, Busse R, Fleming I. Angiotensin-Converting Enzyme (ACE) Dimerization Is the Initial Step in the ACE Inhibitor-Induced ACE Signaling Cascade in Endothelial Cells.Mol Pharmacol 2006 May 01;69(5):1725-32
- 16166094Warner FJ, Lew RA, Smith AI, Lambert DW, Hooper NM, Turner AJ. Angiotensin-converting Enzyme 2 (ACE2), But Not ACE, Is Preferentially Localized to the Apical Surface of Polarized Kidney Cells.J Biol Chem 2005 Nov 25;280(47):39353-62 View 873 categorized literature findings and their references in IPA
Molecular Functions
bradykinin receptor binding, carboxypeptidase activity, chloride ion binding, drug binding, hydrolase activity, hydrolase activity, acting on glycosyl bonds, metal ion binding, metallopeptidase activity, peptidase activity, peptide binding, peptidyl-dipeptidase activity, zinc ion binding
Protein Domains
drug binding, metallopeptidase, N-terminal domain, peptidase, peptide binding, Peptidyl-dipeptidase, Peptidyl-dipeptidase A, transmembrane domain
Subcellular Locations
apical cell surfaces, basolateral cell surfaces, brush border, cell surface, cellular membrane, cytoplasm, exosomes, lysosome, plasma, plasma membrane
